R&D Specialist - CRISPR Technology Development

Tarrytown, NY, United States
Apr 18, 2019
Required Education
Bachelors Degree
Position Type
Full time
Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

The VelociGene team, one of Regeneron's technology centers, is seeking an R&D Specialist to join its efforts in developing CRISPR therapeutics and novel technology platforms to empower disease target identification & validation. This individual is expected to develop, execute, and validate a broad array of cell-based in vitro assays using both primary and established cell lines. Candidates should be highly motivated and able to work independently in a dynamic team environment.

1. Evaluation of in vitro delivered CRISPR/Cas9 factors in primary hepatocyte cultures.

2. Mouse embryonic stem cell culture, lentiviral transduction, and stable cell line generation.

3. Isolating and establishing in vitro cultures of primary hepatocytes from mouse liver.

4. Perform biochemical & cellular analyses such as ELISA, SDS-PAGE/Western blotting, microscopy, FACS/flow cytometry, quantitative PCR, DNA/RNA/protein isolation.

5. Injections, blood draws, and mouse tissue isolation.

6. Independently execute experiments, perform required calculations, plan experimental layouts, and scale up or down from existing protocols as necessary.

7. Maintain clear record of work in a laboratory notebook, updated in a timely and comprehensive manner.

8. Present findings at group meetings, and format data for presentation to senior staff.

This position requires a minimum of a Bachelors degree in a related field of study with 3+ years of experience, or Masters degree with 2+ years of experience. Candidates who have worked with primary hepatocytes or mouse embryonic stem cells will be given priority. Experience must include:

• Expertise in tissue culture.

• Some prior experience working with mice.

• Attention to detail, good organizational & analytical skills, thoughtful time management, capable of multi-tasking effectively, and demonstrated ability to work independently.

This position will require the individual to pass a physical before beginning employment.

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.