Research Associate, Molecular Biology

Employer
AveXis Inc.
Location
San Diego, CA, US
Posted
Apr 18, 2019
Ref
2019-3330
Hotbed
Biotech Beach
Required Education
Bachelors Degree
Position Type
Full time
Overview

Ready to join a team committed to moving gene therapies into the clinical and commercial settings for patients and families devastated by rare neurological genetic diseases? AveXis is advancing cutting-edge science to treat rare and life-threatening genetic diseases starting with our clinical-stage, proprietary gene therapy candidate, AVXS-101 (ZOLGENSMA®). We are in the midst of an incredible journey and are looking for passionate individuals to join us on this important mission.

AveXis, Inc., a Novartis Company , is a clinical-stage gene therapy company, dedicated to developing and commercializing novel treatments for patients suffering from rare and life-threatening neurological genetic diseases. Our initial product candidate, AVXS-101, is our proprietary gene therapy product candidate currently in development for the treatment of spinal muscular atrophy, or SMA, Type 1, the leading genetic cause of infant mortality, and for the treatment of SMA Type 2. The U.S. Food and Drug Administration, or FDA, has granted AVXS-101 Orphan Drug Designation for the treatment of all types of SMA and Breakthrough Therapy Designation, as well as Fast Track Designation for the treatment of SMA Type 1. In addition to developing AVXS-101 to treat SMA Type 1 and Type 2, we also plan to develop other novel treatments for rare neurological diseases, including Rett syndrome (RTT) and a genetic form of amyotrophic lateral sclerosis (ALS) caused by mutations in the superoxide dismutase 1 (SOD1) gene.

The molecular biologist position in research and development (R&D) will be responsible for execution of cloning strategies, site-directed mutagenesis, and additional molecular biology work including ddPCR.

Responsibilities

  • Assists scientists in designing novel constructs, cloning strategies, and delivers constructs to principal scientists leading project teams in a timely manner.
  • Responsible for cross-program molecular biology support, including promoter optimization, cell-based potency assays, and process science construct optimization.
  • Under close supervision, prepare and execute ddPCR of various sample type.
  • Under close supervision, examine data and prepare technical reports, summaries, protocols and quantitative analysis, ensuring experiments are well documented.
  • Maintain and ensure safe laboratory environment and work practices.
  • Help to maintain laboratory and order common supplies.
  • Position requires ability to work collaboratively across a dynamic scientific environment, therefore excellent communication skill, both written and verbal, and strong interpersonal skills.
  • Additional activities as needed.


Qualifications

  • BS with a strong scientific knowledge and research experience in molecular biology, cell biology, biochemistry, bioengineering, or related technical field.
  • Knowledge and experience of cloning and sub-cloning is essential.
  • Knowledge of PCR, gene construct design, and mutagenesis strategies required.
  • Previous industry experience is preferred but not required.
  • Excellent oral and written communication skills.


The level of this position will be based on the final candidate's qualifications.

Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities and activities may change at any time with or without notice.

AveXis is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, national origin, genetics, disability, age, sexual orientation or veteran status.

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