Associate Scientist/ Scientist, Proteostasis Biology in Neurodegeneration

Cambridge, MA, US
Apr 17, 2019
Required Education
Bachelors Degree
Position Type
Full time
We are seeking a cell/molecular biologist, preferably with pharma/biotech background, to join the proteostasis group at the Foundational Neuroscience Center (FNC) in Cambridge, Boston . This individual, with a background in cell biology and/or neuroscience and strong technical expertise in molecular and cell biology, will be responsible for supporting early drug discovery efforts to identify and validate novel drug targets. This individual should enjoy working with novel technologies and thrive in a small biotech atmosphere with the resources of a large pharmaceutical company. This individual's responsibilities will also include assay development and validation, as well as characterization of model systems to study proteostasis biology and its contribution to neurodegenerative disease.

Key Responsibilities:

  • Contribute technical and scientific expertise to proteostasis project teams
  • Execute on a planned experimental design - collect, analyze, interpret and present data
  • Generate robust and complete data sets to support key Go/NoGo decisions on novel drug targets
  • Develop expertise with novel technologies and laboratory techniques
  • Lead and/or assist in writing and revising SOPs
  • Work diligently and efficiently to meet deadlines in a fast-paced environment
  • Read and apply relevant scientific literature
  • Adhere to safety and compliance
  • Participate and present in internal meetings

Position will be hired based on level of experience.
  • BS or MS in biology or related field with 3-5+ years (BS), or 0-2+ years (MS) of pharmaceutical and/or biotech industry experience
  • Proficiency with cell culture techniques, transfection and lentiviral transduction methods
  • Experience working with iPSC-derived neurons and/or primary rodent neurons.
  • Proficiency with cellular analytical techniques such as immunofluorescence microscopy, high-content imaging, and flow cytometry.
  • Skilled with basic laboratory techniques such as ELISA, western blotting, luminescence assays, FRET/fluorescence assays, and qPCR.
  • Aptitude for basic statistics and software packages such as GraphPad PRISM
  • Demonstrated ability to work well in a collaborative team-oriented environment
  • Demonstrated ability to learn, understand and master new experimental techniques
  • Strong organizational skills that enable multitasking and working within timelines
  • Demonstrated record keeping, scientific writing skills, and strong verbal communication skills

Equal Opportunity Employer Minorities/Women/Veterans/Disabled