Senior R&D Specialist (Protein Biochemistry)
- Employer
- Regeneron Pharmaceuticals, Inc.
- Location
- Tarrytown, NY, United States
- Start date
- Apr 16, 2019
View more
- Discipline
- Clinical, Clinical Medicine, Science/R&D, Chemistry
- Required Education
- Bachelors Degree
- Position Type
- Full time
- Hotbed
- Pharm Country, Best Places to Work
Job Details
Summary
We are seeking a Senior R&D Specialist with demonstrated experience using different biophysical and biochemical methods to quantify the physicochemical properties of proteins. The qualified candidate will be responsible for providing in-depth characterization of therapeutic proteins to support research, developability assessments, and early development programs through IND. The candidate is expected to participate in method development and technology innovation efforts aimed to enhance our understanding of biotherapeutic proteins and specifically address both upstream research and late-stage program needs.
Responsibilities
- Conducts biochemical and biophysical characterization experiments on therapeutic protein candidates for investigational-stage regulatory submissions.
- Conducts and provides high quality data for developability assessments of lead candidates.
- Provides input on experimental design and suggests method adaptations to address specific needs of a program or attributes of a molecule.
- Will take on additional responsibilities in advanced method/technology development to support efforts to characterize higher order (secondary, tertiary, quaternary) protein structure, equilibrium protein-ligand complexes, and/or thermodynamic and hydrodynamic interactions in high concentration solutions of therapeutic protein drug candidates.
- Documents experiments, results and findings in electronic laboratory notebook; presents work at group and departmental meetings; contributes to drafting of protocols, method development reports, regulatory submission sections, and peer-reviewed publications.
- Maintain instruments, troubleshoot instrumental/experimental problems, and order/maintain supplies.
Requirements
- BS in Biochemistry, Biophysics, Chemical Engineering, or related field plus 10+ years of relevant experience, or MS in Biochemistry, Biophysics, Chemical Engineering, or related field with 6+ years of relevant experience.
- A strong fundamental understanding of protein structure/function, protein biophysics, statistical mechanics, and general biochemistry.
- Strong grasp of automated chromatography (FPLC, H/UPLC) and spectroscopy (UV-Vis, fluorescence, circular dichroism, or Raman, including stopped-flow techniques).
- Technical proficiency with in silico protein structure prediction and modeling with molecular dynamics/Monte Carlo simulations is highly desirable; programming languages (C/C++ and/or Python) and/or scientific analysis packages (MATLAB, Origin, Igor) is preferred.
- Hands-on experience with static/dynamic light scattering, particularly for analysis of high protein concentration solutions, is an advantage.
- Excellent oral and written communication skills are required.
- Must have strong initiative, drive to complete challenging tasks, and desire to learn new technologies
- Must be capable of multi-tasking, working both independently and within a collaborative environment.
This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.
To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.
Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.
Company
Regeneron is a leading biotechnology company that invents life-transforming medicines for people with serious diseases. Founded and led for 30 years by physician-scientists, our unique ability to repeatedly and consistently translate science into medicine has led to seven FDA-approved treatments and numerous product candidates in development, all of which were homegrown in our laboratories. Our medicines and pipeline are designed to help patients with eye disease, allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, infectious diseases, pain and rare diseases.
Regeneron is accelerating and improving the traditional drug development process through our proprietary VelociSuite® technologies, such as VelocImmune® which produces optimized fully-human antibodies, and ambitious research initiatives such as the Regeneron Genetics Center, which is conducting one of the largest genetics sequencing efforts in the world.
Stock Symbol: REGN
Stock Exchange: NASDAQ
- Website
- https://www.regeneron.com/
- Phone
- 914-847-7000
- Location
-
Corporate Headquarters
777 Old Saw Mill River Road
Tarrytown
New York
10591
United States
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