Scientist/Radiochemist - Positron Emission Tomography (PET) Imaging

Location
Tarrytown, NY, United States
Posted
Apr 16, 2019
Ref
15645BR
Required Education
Doctorate/PHD/MD
Position Type
Full time
Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

Summary
We are seeking a highly motivated scientist to join our growing Positron Emission Tomography (PET) imaging team. This position will be responsible for performing radiolabeling of antibodies, antibody fragments, and small molecules with short-lived radioisotopes such as F-18, Ga-68, Cu-64, Y-86, and/or Zr-89 etc. Radiolabeled compounds will be used in preclinical in vivo imaging studies in research areas including Oncology, Immune-oncology, Infectious Disease, and others at Regeneron. The qualified individual should have strong hands-on experience in radiochemistry and conjugation chemistry techniques and characterization.

Responsibilities:

• Develop procedures for radiolabeling of antibody fragments with F-18 via a prosthetic group such as N-succinimidyl flourobenzoate (SFB) or other and have familiarity with commercial automatic synthesizers.

• Develop procedures for radiolabeling F-18 via AlF-NOTA conjugated antibody fragments or small molecules.

• Perform conjugation and radiolabeling protocols for Zr-89, Ga-68, Cu-64, Lu-177 and/or other radioisotopes for imaging and
radioimmunotherapy

• Evaluate serum stability of radiolabeled compounds in vitro and/or ex vivo

• Experience in various purification methodologies and in vitro characterization approaches.

• Organize and analyze data, present results in group meetings and project team meetings

• Coordinate with other groups to align timelines and activities to carry out in vivo imaging/biodistribution studies in animals.

• Write documents to support IND filings, patent applications, external conference posters and papersLI-CB1
Requirements:
This position requires a minimum of a Ph.D with 2-5 years working experience with radiolabeled protein/antibody conjugates and/or small molecules for diagnosis/therapy of cancer and other diseases. This experience must include hands-on experience with current radiochemistry and conjugation chemistry protocols as well as purification and quality control methods. Experience in cell culture, in vitro cell-based assay a plus. The ability to execute deadlines in multidisciplinary teams and deliver high quality data with attention to detail, as well as the ability to work creatively and collaboratively in a dynamic team environment with excellent interpersonal skills are critical.

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.