Scientist I/II, Conjugation Chemist

Employer
AbbVie
Location
Worcester, MA, US
Posted
Apr 13, 2019
Ref
1902611
Required Education
Bachelors Degree
Position Type
Full time
AbbVie Bioresearch Center in Worcester, MA has an opening for a Scientist I/II in Discovery to conduct pre-clinical research and development in the area of antibody drug conjugates (ADCs).

Key Responsibilities Include:

  • Synthesis, purification and characterization of ADCs on mg to gram scale under minimal supervision.
  • Optimization and validation of conjugation protocols and formulation buffers.
  • Optimization of automated techniques for ADC synthesis and purification.


Position will be hired based on level of experience.

  • BS or MS degree with 5-8+ (BS) or 2-5+ (MS) years of experience in Analytical Chemistry, Biochemistry, Chemistry or other relevant discipline.
  • Knowledge and experience in laboratory scale protein purification, employing Hydrophobic Interaction Chromatography (HIC), Size Exclusion Chromatography (SEC), Ion-Exchange (IEX), mixed mode chromatography and affinity chromatography. Experience with GE AKTA FPLC and unicorn software preferred.
  • Previous experience in the discovery and development of Antibody-Drug Conjugates, including hands-on experience with the conjugation and purification process is desired.
  • Hand on experience in analytical techniques including HIC-HPLC, SEC, IEX, RP-HPLC, and capillary electrophoresis (e.g. reduced and non-reduced CE-SDS, icIEF).
  • This position requires an individual who is self-motivated, enthusiastic, hard-working, detail-oriented, with demonstrated problem solving skills who is able to work in a fast-paced team environment. High-quality written and oral communication skills and the ability to excel in a collaborative environment are essential.