Senior Scientist I, Conjugation Chemist

Worcester, MA, US
Apr 13, 2019
Required Education
Position Type
Full time
AbbVie Bioresearch Center in Worcester, MA has an opening for a Senior Scientist in Discovery to conduct pre-clinical research and development in the area of antibody drug conjugates (ADCs).

Key Responsibilities include:

  • Synthesis, purification and characterization of ADCs on mg to gram scale.
  • Development and optimization of conjugation protocols utilizing novel chemistries and technologies.
  • Development and optimization of automated techniques for ADC synthesis and purification.
  • Collaboration with Therapeutic Area Project Teams, as well as core Chemistry, Protein Science and Process Development teams to expand conjugation capabilities at Abbvie.

  • PhD in Organic Chemistry/ Biochemistry/Chemical Biology or other relevant discipline with 0-3+ years of relevant experience.
  • Hands-on experience with generation and characterization of antibody drug conjugates preferably in the area of biotherapeutics.
  • Proficient in analytical techniques including Hydrophobic Interaction Chromatography (HIC)-HPLC, Size Exclusion Chromatography (SEC), Liquid chromatography-mass spectrometry (LC-MS), Ion-Exchange (IEX), Reversed Phase (RP)-HPLC, and capillary electrophoresis (e.g. reduced and non-reduced CE-SDS, icIEF).
  • Hands-on experience and knowledge in protein purification using HIC, IEX, SEC and affinity chromatography. Experience with GE AKTA FPLC and unicorn software preferred.
  • This position requires an individual who is self-motivated, enthusiastic, hard-working, detail-oriented and able to work in a fast-paced team environment with demonstrated problem solving skills.
  • High-quality written and oral communication skills and the ability to excel in a collaborative environment are essential.