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Senior Scientist I, Conjugation Chemist

Employer
AbbVie
Location
Worcester, MA, US
Start date
Apr 13, 2019

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Discipline
Science/R&D, Biotechnology, Chemistry
Required Education
Doctorate/PHD/MD
Position Type
Full time
Hotbed
Genetown, Best Places to Work
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Job Details

AbbVie Bioresearch Center in Worcester, MA has an opening for a Senior Scientist in Discovery to conduct pre-clinical research and development in the area of antibody drug conjugates (ADCs).

Key Responsibilities include:

  • Synthesis, purification and characterization of ADCs on mg to gram scale.
  • Development and optimization of conjugation protocols utilizing novel chemistries and technologies.
  • Development and optimization of automated techniques for ADC synthesis and purification.
  • Collaboration with Therapeutic Area Project Teams, as well as core Chemistry, Protein Science and Process Development teams to expand conjugation capabilities at Abbvie.


  • PhD in Organic Chemistry/ Biochemistry/Chemical Biology or other relevant discipline with 0-3+ years of relevant experience.
  • Hands-on experience with generation and characterization of antibody drug conjugates preferably in the area of biotherapeutics.
  • Proficient in analytical techniques including Hydrophobic Interaction Chromatography (HIC)-HPLC, Size Exclusion Chromatography (SEC), Liquid chromatography-mass spectrometry (LC-MS), Ion-Exchange (IEX), Reversed Phase (RP)-HPLC, and capillary electrophoresis (e.g. reduced and non-reduced CE-SDS, icIEF).
  • Hands-on experience and knowledge in protein purification using HIC, IEX, SEC and affinity chromatography. Experience with GE AKTA FPLC and unicorn software preferred.
  • This position requires an individual who is self-motivated, enthusiastic, hard-working, detail-oriented and able to work in a fast-paced team environment with demonstrated problem solving skills.
  • High-quality written and oral communication skills and the ability to excel in a collaborative environment are essential.

Company

AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, and YouTube.

Stock Symbol: ABBV

Stock Exchange: NYSE

Company info
Website
Phone
1-800-255-5162
Location
1 North Waukegan Road
 North Chicago
Illinois
60064
US
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