Bristol-Myers Squibb Company

Scientist I

Location
Redwood City, CA, United States
Posted
Apr 12, 2019
Ref
R1513259
Required Education
Doctorate/PHD/MD
Position Type
Full time
We are seeking a skilled and enthusiastic Protein/Antibody engineer to join the Protein Engineering Group. The candidate will be expected to work on a variety of protein engineering projects to optimize and generate differentiated antibody therapeutic leads.

Specific Responsibilities

Lead protein engineering efforts to engineer antibodies and antibody fusion proteins with novel properties

Optimize variable and constant domains of antibodies to generate therapeutic leads.

Elucidate mechanistic understanding of targets and work to progress targets through pipeline

Independently perform complex experiments with strong attention to detail and documentation.

Excellent written and oral skills are necessary.

Accomplish goals under project team time lines.

Qualifications

Ph.D. in Biochemistry, Antibody engineering, chemical engineering, structural biology, or similar fields with 2-5 years post Ph.D. experience.

Knowledgeable in engineering novel functionalities into antibodies (such as cytokines, modulating FcgRs, or FcRn interactions)

Understanding of structure-function of proteins

Experience and knowledge of molecular biology, protein expression, purification, and characterization required.

Experience in utilizing various display technologies is a plus (yeast, phage, mammalian systems)

Immunology/Oncology experience including in-vitro cell-based assays is desirable

Excellent time management and organizational skills.

Demonstrated ability to work in a multidisciplinary biologics discovery team.