Research Technologist- Stem Cell Core

San Francisco, California, US
Apr 05, 2019
Required Education
Associate Degree
Position Type
Full time

The Gladstone Institutes is an independent, not-for-profit research institution affiliated with the University of California San Francisco (UCSF), contributing to the health and well-being of all people through medical research, education, and outreach in the areas of heart disease, HIV/AIDS, and neurological disease. Gladstone is composed of three separate institutes and approximately 400 employees. Our employees receive exceptional benefits. We are located in an award-winning building adjacent to UCSF's Mission Bay Campus. Gladstone has consistently ranked as one of the top places to work in academia in the United States.


Cell Culture and Molecular Biology Duties
  • Culture, expand, catalog and disseminate human induced pluripotent stem cells (hiPSCs), primary fibroblasts, primary peripheral blood monouclear cells for experiments.
  • Perform quarterly mycoplasma testing on all GSCC-cultured cell lines and report results effectively to users.
  • Perform cell type differentiation of hiPSC lines using established protocols.
  • Provide stem cell technique training to researchers.
  • Perform PCR for genetic analysis testing.
  • Perform genome editing and cell cloning in hiPSCs using CRISPR editing technology.

Operational & Lab Management Duties
  • Interact and communicate effectively with many multinational researchers weekly.
  • Must be comfortable with managing/executing core operational duties, such as:
  • Maintain a well-stocked stem cell core
  • Operate core facility functions semi-independently
  • Enforce core rules, procedures and guidelines
  • Serve as a primary contact for equipment malfunctions/repairs
  • Report necessary equipment repairs to our Facilities team, with follow-through to ensure repair/replacement
  • Communicate with vendors to negotiate discount pricing for equipment/materials/services
  • Arrange for sample testing and equipment demonstrations with vendors
  • Readily provide expert advice on stem cell culture to researchers and problem-solve with feasible solutions.
  • Work with other Gladstone core managers on applications specific to core facilities.
  • Work with department lab managers and lab aides to coordinate common operational procedures.
  • Have or develop working knowledge of general laboratory equipment functionality and troubleshoot problems.
  • Stay informed about stem cell related products and services, and disseminate product/service literature to the Gladstone stem cell community.
  • Become familiar with our online ordering system; compile monthly recharges for accounting; configure/adjust pricing schemes as needed
  • Manage time appropriately in an environment requiring attention to numerous activities.
  • Report to Core Director regularly, prepare reports, and attend core operational meetings



  • B.S. in a field of Biological Sciences, preferred. Certification in Stem Cell Science is a plus.
  • Minimum 1-2 years of hands-on cell culture and molecular biology experience.
  • Experience with hiPSC derivation and differentiation is preferred.
  • Experience working with scientists to provide research support and laboratory management.
  • Must be available most weekends for limited cell culture work.
  • Should be resourceful, creative and proactive to seek out answers/solutions when encountering problems outside range of expertise.
  • Must be comfortable implementing operational modifications where necessary, with direction from the Core Director, to improve accuracy, efficiency, and cost-effectiveness.

The role of the candidate is to assist researchers to attain ambitious research goals by providing support services, resources and an organized, well-maintained core facility. The ideal candidate will be motivated to facilitate cutting-edge, disease-related research in a modern scientific core facility and employ their own desire to provide order to the sometimes-chaotic environment of a busy laboratory setting. The candidate must be able to adapt well to shifting demands, and be willing to learn new scientific methods. Excellent verbal and written communication skills are required. The candidate should be comfortable working collaboratively and cohesively in a small team, and be able to interact with bench scientists at all levels.