Eli Lilly and Company

Principal Research Scientist - ADME

Location
Indianapolis, IN, United States
Posted
Apr 01, 2019
Ref
48306
Required Education
Doctorate/PHD/MD
Position Type
Full time
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.

Responsibilities

Have you gained expertise in and had direct responsibility for biopharmaceutics, pharmaceutical chemistry, drug-metabolism, pharmacokinetics/bioanalytical, or translational/predictive drug disposition? Do you desire to continue growing in your career and make a real impact in lives of patients? Do you have experience in regulatory interactions, document authorship as well as an understanding of global regulatory guidances? Are you looking for an opportunity to use your firsthand experience with computational modeling of DMPK endpoints in discovery (e.g., structure-property-relationship) or development (e.g., prediction of clinical drug-drug-interactions)? Consider joining our dynamic team of scientists working for a dedicated company striving to improve the lives of our patients.

Lilly's Drug Disposition team is searching for an experienced pharmaceutical scientist to lead discovery and development of absorption, distribution, metabolism, excretion (ADME) science within cross-functional teams to advance our portfolio. Our diverse group is multidisciplinary, utilizing in vitro, in vivo, and in silico approaches to mechanistically study the pharmacokinetics, absorption, and disposition of new chemical entities. You will serve as technical leader within the department and across portfolio cross-functional teams. You will engage in experimental design and data interpretation to deliver the discovery and development portfolio of investigational targets and novel therapeutics. We are passionate about making an impact in the lives of our patients and hope you'll consider joining our efforts.
Responsibilities
  • Accountable for the delivery of meticulously designed, mechanistically-informed and scientifically integrated data packages to guide compound selection, study design, and portfolio decisions in both pre-clinical discovery and clinical development.
  • Partner with cross-functional colleagues including Toxicology, PKPD, Biology and Medicinal Chemistry to assess and, where possible, ameliorate drugability and development risk through effectual data analyses and study conduct.
  • Lead R&D initiatives to grow ADME capabilities across experimental and drug modalities.
  • Integrate in vitro, in vivo, and in silico ADME data with Biology and Medicinal Chemistry colleagues to define structure-activity- and structure-property-relationships and deliver favorable molecular and experimental design strategies.
  • Prepare preclinical data packages to support global regulatory submissions and correspondence as well as represent ADME data in face-to-face discussions with regulators.
  • Guide junior, peer, and upper level scientists in best and contemporary practices of multi-property optimization through the use of mechanistic ADME principles.
  • Communicate efficiently and network across groups, including interdisciplinary teams, regulatory agencies, and functional groups within drug disposition.
48306BR

Basic Qualifications
  • Ph.D. degree in Drug Metabolism, Pharmacokinetics, or Pharmaceutics, or an advanced degree in a related science with extensive training in the field of drug metabolism and disposition.
  • Experience in drug discovery and development, primarily small molecule, for 5 years or more.


Additional Skills/Preferences
  • Mechanistic understanding of drug clearance and excretion pathways and the clinical translation of preclinical data, including the use of physiologically-based pharmacokinetic (PBPK) models.
  • Demonstrate strong communication skills with the ability to integrate diverse perspectives, adroitly deliver critical messaging, and influence leaders/key partners.
  • Ability to handle multiple simultaneous projects and run contesting priorities.
  • A deep understanding of first-principles in biopharmaceutics, drug absorption, metabolism, transport, clearance, and pharmacokinetics, along with an ability to clearly communicate theories and concepts.
  • Experience with drug disposition risks and issues in one or more of the following disease areas: neuroscience, neuro-degeneration, neuro-pain, and/or endocrine, diabetes, end-organ disease/dysfunction.
  • Experience with enabling studies and regulatory requirements for first-in-human studies; experience in clinical development.
  • Collaborative team behaviors and desire to build and sustain relationships with R&D customers and the wider scientific community.
  • Hands-on experience with modeling software (e.g. SimCYP, GastroPlus, PKSim).


Additional Information
  • Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
  • If you are currently in a technical path role, but outside of the posting band, you may apply. You will be hired at your current level. For example: Current P4 (tech ladder), Posting R1-2 tech ladder, hire will occur at P4.