Senior Research Associate I, Protein Sciences - Research

Location
San Rafael, CA, United States
Posted
Mar 27, 2019
Ref
21242
Discipline
Science/R&D, Research
Required Education
Associate Degree
Position Type
Full time
BioMarin is the world leader in delivering therapeutics that provide meaningful advances to patients who live with serious and life-threatening rare genetic diseases. We target diseases that lack effective therapies and affect relatively small numbers of patients, many of whom are children. These conditions are often inherited, difficult to diagnose, progressively debilitating and have few, if any, treatment options. BioMarin will continue to focus on advancing therapies that are the first or best of their kind.

BioMarin's Research & Development group is responsible for everything from research and discovery to post-market clinical development. Research & Development involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with rare diseases. Come join our team and make a meaningful impact on patients' lives.

SUMMARY DESCRIPTION

We are

seeking a

highly motivated

S enior Research Associate

to join our Biologics & Production Team. The successful

candidate

will

play

an important role in the discovery-stage research of

protein

and gene therapy-based

biotherapeutics. The

candidate

will

work

within multidisciplinary teams of scientists/research associates to provide experimental

expertise in

purifying and characterizing

therapeutic

candidates .

He or she also

will have the opportunity to develop processes that empower do wnstream production efforts to

support

the rapid

scale up

of preclinical stage therapeutics.

This position involves a unique blend of

discovery,

experimental ,

and

development

skills in

protein science and

gene therapy

to support both discovery- and development-stage processes for novel therapeutics.

RESPONSIBILITIES

As

a Senior Research Associate in Biologics & Production Group , the

associate

will

be responsible for

developing and executing standard a s well as

novel purification

methods

to produce and characterize

first in class

biological

therapeutics .

The candidate will

work

independently , and as part of a team ,

to support discovery efforts in research.

The ideal

candidate wi ll have

a

strong

background in

protein science with a demonstrated track record of accomplishments producing proteins of multiple classes.

Responsibilities

include :

Purification

of tagged and untagged proteins from bacterial and mammalian sources.

Character iz ation of purified proteins

using

a variety of analytical tools including

AEX-, CEX-, SEC- HPLC, SDS-PAGE,

and

potency as determined by affinity

Purif ica t i on of

AAV

gene therapy vectors using

multiple

approaches

Perform purification methods at multiple scales, including using high-flow equipment

Development of

scalable

purification

methods that can accelerate process sciences

Design, execute,

interpret

experimental results documenting work in ELN

Prepare slides, propose solutions,

and present

results

at proje ct

team meetings

Identify and implement new technologies or improved approaches in protein

sciences

EXPERIENCE

Track record of success purifying proteins at

small and large-scale on

the

Akta

Pure and

Avant

platforms .

Experience

performing

ultrafiltration/ diafiltration , and clarification processes .

Experience

d evelop ing new

protein purification

methods ,

exploring new tools for protein

characterization

Familiar

with Unicorn and

C hemS tation

instru ment software

Experience using the Octet Platform for protein

quantitation and kinetic studies

is a plus

Experience supporting

development-stage programs (process development, formulation, etc.)

is preferred

The ideal candidate not only demonstrates a thor ough understanding of protein

science s , but also possesses complementary technical skills in

lab innovation and the development and application of novel techniques to solve challenging problems .

Experience

with robotics

and other high throughput technologies to accelerate discovery and development is a plus .

The candidate must demonstrate an ability to collaboratively work in teams of scientists/research associates with diverse backgrounds, and efficiently manage

their

time in a fast-paced work environment. Excellent oral and written communication skills, and a high degree of personal responsibility are valued.

This role directly handles and/or is in proximity to lentiviral or other viral vector based gene delivery systems

EDUCATION & REQUISITES:

Bachelor's degree in Biology or a related

scientific field and at least 6-8

years of relevant experience or

Master's degree with at least 4 -6

years of relevant experience.

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law.

~BIO