Scientist 1/ Scientist 2, Gene Regulation (Molecular Biology/Informatics)

Location
94608, Emeryville
Posted
Mar 26, 2019
Ref
CC 2
Required Education
Doctorate/PHD/MD
Position Type
Full time

4D is in need of a talented and motivated Scientist 1/ Scientist 2 to join our team in supporting our viral drug therapy research efforts as we contribute to the future of gene therapeutics. 

Responsibilities include but not limited to:

  • Demonstrating innovative design, development, and execution of research projects through literature review, expertise, and scientific teamwork
  • Mining databases for information useful for the construction of novel regulatory elements
  • Design, execution and analysis of next-gen analytical techniques such as ssRNA-Seq, ChIP-Seq, etc.
  • Designing and constructing novel AAV-compatible promoters and regulatory elements for in vitro analysis and proof-of-concept animal studies
  • Contributing to the design, implements, and interprets the results of experimental studies
  • Contributing to the design, optimization, verification, and execution of current and new assays
  • Writing study reports and manuscripts and presenting results at appropriate scientific meetings
  • Maintaining compliance to company Environmental Health and Safety policies, procedures, and practices
  • Performing hands-on research in company’s lab to move scientific projects forward
  • Effectively mentoring junior level staff and acting as a resource for providing scientific expertise
  • Contributing to building a culture that embraces continuous learning, improvement and innovation and encourages team members to expand their technical skill base and deepen their gene therapy expertise.
  • Utilizing appropriate scientific approaches to understand characteristics of gene expression regulatory elements to drive decisions and assess potential application of company’s lead adeno-associated virus vectors and products
  • Maintaining a current awareness and contributes to current scientific literature; actively applies new concepts and technologies as appropriate
  • Leading and supporting research initiatives such as new technology development and platform improvement projects
  • Leveraging strong understanding of gene therapy principles to design, assess and interpret experimental data, then uses the resulting information to inform selection of the optimal vector delivery strategy
  • Designing and implementing appropriate experiments to help predict the in vivo bio-performance of potential gene therapies

Requirements:

  • Ph.D. degree and at least two years of post-doctoral experience in one of the following disciplines: Bioengineering, Bioinformatics, Molecular Biology, Cell Biology, Biochemistry or a related field
  • Facility in mining databases for information useful for the construction of novel regulatory elements
  • Experience in design, execution and analysis of next-gen techniques such as ssRNA-Seq, ChIP-Seq, etc.
  • Ability to program in relevant languages (Python, C, etc.)
  • Knowledge and working experience in viral gene therapy vector and/or product pre-clinical research and development (adeno associated viral vectors preferred)
  • Background in promoter or regulatory element engineering preferred
  • Solid proficiency in molecular biology and protein chemistry techniques such as molecular cloning, PCR, RT-PCR, mammalian cell culture, immunoblot, plasmid transfection, ELISA, and immunocytochemistry/immunohistochemistry procedures.
  • Successful demonstrated ability to work independently in designing, developing, and executing new assay methods
  • Successful demonstrated ability to rigorously analyze and interpret data
  • Ability to multi-task and support more than one project simultaneously
  • Ability to work cooperatively in a team-based environment; supportive of multiple viewpoints and approaches
  • Understanding and knowledge of key scientific software programs (including Microsoft Office, JMP or Prism, and Adobe Photoshop)
  • Strong organizational skills, analytical skills, and problem-solving skills
  • Strong communication skills (both written and oral) with demonstrated ability to present ideas, information and data effectively via one on one discussions, team meetings, and external partnership interactions

We are 4D Molecular Therapeutics (4DMT) -- a global leader in gene therapy product research & development using scientific innovation to unlock the full potential of gene therapy for patients with genetic diseases. Our goal is to design and develop transformative gene therapy products using our proprietary adeno-associated virus variants platform to treat serious unmet medical conditions.  

While AAV gene therapy pioneers are making great strides with the first wave of products, hurdles still exist with the use of 1st & 2nd generation vectors (naturally occurring primitive viral capsids).  4DMT’s next-generation Therapeutic Vector Evolution platform generates targeted, optimized and proprietary AAV vectors that have the potential to overcome the delivery and immunological challenges currently facing the field, ultimately unlocking the full potential of gene therapy.

We invite all of you who share our passion and vision in creating the ultimate gene therapy products to cure severe genetic and rare diseases with high unmet medical need.  We seek the best people in the industry who identify with our mission and innovative results-driven approach. We offer an inspiring and collaborative environment that encourages individual contributions, recognizes performance in multiple ways, offers uniquely generous benefits and provides challenging opportunities for career development.