R&D Associate, Viral Vector Technologies

Location
Tarrytown, NY
Posted
Mar 25, 2019
Ref
15637BR
Required Education
Associate Degree
Position Type
Full time
Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

Summary

Regeneron is currently seeking a talented and motivated Research Associate/Research Specialist to join a technology development group which aims to develop novel viral vectors. The successful candidate should have a strong background working in vivo with rodent models, specifically mice. Experience working with Adeno-associated virus (AAV) or in vivo tumor models is a plus. Incumbent should be able to work methodically and with minimal supervision. His/her main goal will be to characterize novel AAV viral vectors in vivo by designing, executing and analyzing studies in mice to determine the biodistribution of engineered vectors in various mouse models, using a variety of assays to measure infection such as bioluminescent imaging, immunohistochemistry, and qPCR.
Specific experience should include mouse handling, various injection techniques, and basic molecular biology. Mammalian cell culture experience is a plus.
#LI-JNH1
JNH1

Responsibilities

In his/her role within the team, the incumbent will have to:
1. Manage, organize and prepare working stocks of candidate viral vectors in BLS2 cell culture for in vivo studies
2. Dose mice with viral vectors and/or other treatments via tailvein injection, IP, IM, or SubQ route
3. Monitor infection through in vivo bioluminescent imaging or by blood draws and serum collections
4. Collect biological samples from infected mice through dissections; process samples appropriately for downstream analysis (immunohistochemistry, qPCR, RNAScope)
5. Perform basic biochemical/immunological assays (ELISA, flow cytometry)
6. Perform basic molecular biology assays (Cloning, Western blotting, DNA/RNA extractions, PCR, RT-PCR, quantitative PCR, etc.)
7. Analyze and present data
8. Maintain lab supplies and help with lab organization

Requirements
TECHNICAL SKILLS:
Animal handling, animal injections (specifically tailvein), bleeds and serum collection, dissection techniques, bioluminescent imaging, virology, basic molecular biology/biochemistry, cell biology, ELISAs

CORE COMPETENCIES:
- Incumbent must have experience in working with mice, specifically injecting compounds via various routes of injection (tailvein is important)
- Incumbent should be skilled in designing well-controlled experiments that can provide reliable results
- Incumbent should be able to analyze data and extract conclusions
- Experience with mouse dissections and tissue analysis by various methods is desired
- Incumbent should have experience with basic safety procedures and sterile techniques required for BSL2 laboratory function
- A general understanding of microbiology and general immunology is preferred
- Understanding of and experience with in vitro assays with viral vectors will be a distinct advantage

Education:
Minimum 3 years of research experience.
Minimum educational requirement: Bachelor's Degree; Master's degree desired.

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.