Amgen

Scientist, Translational Immunology

Employer
Amgen
Location
South San Francisco, CA, US
Posted
Mar 22, 2019
Ref
R-62489
Required Education
Associate Degree
Position Type
Full time
Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology.

Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.

The Translational Immunology laboratory within the Comparative Biology and Safety Sciences organization at Amgen is seeking a highly motivated Scientist to independently investigate the mechanisms of immune related safety events in preclinical species and humans.

Responsibilities:

Make major scientific laboratory-based contributions to the goals of the immunotoxicology group

Develop predictive safety assays

Interact with colleagues at multiple research sites to develop novel and creative experimental solutions that enable efficient and innovative drug development practices

Design, conduct and communicate experiments that provide solutions for immune related safety issues

Interface with project teams and represent the immunotoxicology group internally and externally through contributions to projects, presentations, collaborations and publications

Survey the literature and conferences and stay up to date with novel technologies. Assess and apply them into experimental opportunities.

Collaborate with scientists from oncology, inflammation, neuroscience and cardiometabolic disorders to advance Amgen's innovative pipeline

Work closely with toxicologists and interdisciplinary scientists from areas such as biologics, bioinformatics, proteomics, genome analysis unit,

Mentor Research Associates and aid their scientific and career development

Basic Qualifications:

Doctorate degree

OR

Master's degree and 4 years of scientific experience

OR

Bachelor's degree and 6 years of scientific experience

Preferred Qualifications:

PhD in immunology, molecular or cell biology or a closely-related life sciences discipline.

3+ years of research experience in the area of cellular and/or molecular immunology

Demonstrated track record of independent critical thinking and scientific achievement in the area of immunology

Excellent verbal and written communication and presentation skills

Ability to balance moving projects forward in the face of continuously evolving priorities and timelines while creating an environment of scientific curiosity promoting the exchange of ideas

Expertise in the following areas:

Establishing complex cell-based assays from cell lines and or primary cells. Cell culture, maintenance of cell lines

Magnetic and other cell isolation and enrichment techniques of primary cells, sample preparation for downstream cellular and or molecular analyses

Experience with peripheral blood mononuclear cells, whole blood and other tissues from various species

Multicolor flow cytometry and or CyTOF

Various soluble immunoassays (ELISA, MSD, Luminex and others).

Integrated understanding of complex datasets and ability to synthetize data; plan and execute next steps based on experimental results