R&D Associate - Cell Based Assay for lead Antibody Selection

Location
Tarrytown, NY
Posted
Mar 22, 2019
Ref
15547BR
Required Education
Bachelors Degree
Position Type
Full time
Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

Summary
The Bioassay group within the Therapeutic Proteins Department seeks a highly motivated and energetic Research Associate who will perform experiments for the in vitro characterization of preclinical and clinical drug candidates in Regeneron's pipeline. Responsibilities will include development of cell-based assays to measure the biological activity of antibodies and to support screening and lead candidate selection. The individual will also execute experiments utilizing primary cells to characterize preclinical antibodies to support regulatory filings. The ideal candidate will have experience with mammalian cell culture, primary cell isolation, flow cytometry and cell-based bioassays such as luciferase or proliferation assays.

Responsibilities
- Mammalian cell culture
- Run and troubleshoot cell-based bioassays
- Generation of stable cell lines via plasmid- and virus-based techniques
- Perform flow cytometry to evaluate antibody binding to the proteins of interest on the cell surface.
- Isolation of PBMCs for use in primary cell assays to assess effects such as cytokine release or effector function
- Plan experiments, including proper controls
- Analyze data accurately and in a timely manner
- Record data in an electronic notebook in an accurate and timely manner
- Communicate with supervisor and other lab members in an effective manner
- Present data within and outside the group clearly and concisely
Requirements:
This position require a minimum of a Bachelor's Degree with 2-4 years of experience (or MS and 1-2). Experience should include:
- Cell Culture (adherent and non-adherent cells)
- Flow Cytometry
- Luciferase Reporter Assays
- Primary cell isolation and assays
- Stable cell line generation
- Excellent communication skills
- Team Player

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.