Immune Cell Engineering Scientist/Senior Scientist

Caribou Biosciences, Inc. is a leading company in CRISPR genome engineering located in Berkeley, CA. Caribou's tools and technologies provide transformative capabilities to therapeutic development, agricultural biotechnology, industrial biotechnology, and basic and applied biological research. The six-year-old company has developed a best-in-class CRISPR genome engineering technology platform and has a leading intellectual property position. 

We are seeking an immune cell engineering Scientist/Senior Scientist to join our Functional Genomics group in Berkeley. The successful candidate will demonstrate a thorough understanding of immunology as it relates to tumor biology and have a strong record of being able to move projects forward to product development. This is an opportunity for a talented scientist to work in a highly matrixed team environment to drive discovery and shape Caribou’s next-generation cell therapy programs.

Responsibilities include:

• Working with a highly matrixed team to develop and advance preclinical allogeneic CAR-T cell programs targeting liquid and/or solid tumors
• Platform development to engineer a diverse range of immune cell types
• Creative thinking to propose and implement innovative cell engineering approaches to expand Caribou’s preclinical pipeline and intellectual property
• Designing, coordinating, executing, and analyzing in vitro and in vivo experiments
• Communicating results clearly and concisely internally and externally
• Keeping accurate record of experiments and results

Candidate must possess:

• PhD in immunology, molecular biology, cell biology, or a closely related field
• Minimum 2 years of relevant experience
• Hands-on proficiency in primary immune cell isolation and culture
• Experience in planning and executing in vitro functional assays to characterize primary immune cells including, but not limited to, cytotoxicity assays, cytokine/chemokine measurements, and proliferation assessment
• Experience in multi-parameter flow cytometry and data analysis
• Hands-on experience with cell-line derived, PDX, or GEM murine tumor models
• Excellent interpersonal, verbal, and written communication skills are essential in our collaborative research environment
• Ability to develop and mentor a team of researchers
• Comfort in a fast-paced environment and ability to adjust workload based upon changing priorities

Desired experience:

• Deep understanding of cell-engineering techniques
• Prior experience with cell therapies or other biologics
• Work in pharmaceutical or biotechnology company focused on immuno-oncology
• Understanding of regulatory guidelines for cell therapies

Caribou Biosciences, Inc. is a dynamic start-up company, and the successful candidate must have the ability and desire to work in a fast-paced environment. For more information, please visit www.cariboubio.com. Caribou is on Twitter. Sign up to follow our Twitter feed @CaribouBio.

Caribou offers a comprehensive compensation package, as well as generous paid time off in addition to Company-observed holidays. The Company provides medical, dental, and vision insurance, along with a 401(k) retirement savings plan which includes matching employer contributions. Caribou promotes a culture in which employees are respected and rewarded for hard work, innovation, personal initiative, and teamwork. 

Caribou is an equal opportunity employer and does not discriminate on the basis of race, color, religion, citizenship, political activity or affiliation, marital status, age, national origin, ancestry, physical or mental disability, medical condition (as defined under California law), veteran status, sexual orientation, gender identity, gender expression, sex or gender (which includes pregnancy, childbirth, breastfeeding, or related medical conditions), taking or requesting statutorily protected leave, or any other basis protected by law. In addition, Caribou prohibits the harassment of any individual on any of the bases listed above or any other characteristics protected under federal, state, or local laws.

Direct applicants only. No agencies please.