Technology Development Research Associate

Location
Berkeley, CA
Posted
Mar 21, 2019
Required Education
Bachelors Degree
Position Type
Full time

Caribou Biosciences, Inc. is a leading company in CRISPR genome engineering located in Berkeley, CA. Caribou's tools and technologies provide transformative capabilities to therapeutic development, agricultural biotechnology, industrial biotechnology, and basic and applied biological research. The six-year-old company has developed a best-in-class CRISPR genome engineering technology platform and has a leading intellectual property position. 

The Technology Development Group is seeking an enthusiastic and driven Research Associate to develop improved genome editing technologies and methods.  The Candidate will interact closely with Caribou Scientists to develop cell handling protocols for use with novel gene editing tool. Primary responsibilities will be the culture and transfection of mammalian cells with ribonucleoprotein (RNP) complexes, and analysis of next generation sequencing (NGS) data from in cell editing experiments. A successful candidate will have extensive hands-on experience with mammalian cell culture, be familiar with various transfection methods with various material types and have an understanding of published genome editing work. The ideal candidate will contribute to the discovery and development of novel immune cell therapeutics currently in pre-clinical development.

Responsibilities will include:

  • Mammalian cell culture, including isolation, culture and manipulation of primary cells
  • Generation and characterization of genetically modified immune cells
  • Assay development and implementation of gene-editing technologies in primary cells
  • Immune cell biology-based assay development and implementation in the context of an allogeneic CAR-T preclinical program

Candidate must possess:

  • B.Sc. or equivalent in Cell Biology, Biochemistry, Bioengineering, or Molecular Biology
  • Minimum of 2-3 years’ experience working in either Academic Laboratories or the Biotech Industry
  • Broad experience in mammalian cell culture and transfection of multiple cell types
  • Understanding of genome editing technologies
  • Strong organizational skills and ability to stay abreast of current literature
  • Excellent written and verbal communication skills

Additional positives:

  • Experience optimizing and developing transfection protocols
  • Understanding of DNA repair mechanism and pathways
  • Experience designing low and medium throughput screens
  • Familiarity running FACS analysis for cell surface phenotyping

Caribou Biosciences, Inc. is a dynamic start-up company, and the successful candidate must have the ability and desire to work in a fast-paced environment.  For more information, please visit www.cariboubio.com.  Caribou is on Twitter.  Sign up to follow our Twitter feed @CaribouBio.

Caribou offers a comprehensive compensation package, as well as generous paid time off in addition to Company-observed holidays.  The Company provides medical, dental, and vision insurance, along with a 401(k) retirement savings plan which includes matching employer contributions. Caribou promotes a culture in which employees are respected and rewarded for hard work, innovation, personal initiative, and teamwork.

Caribou is an equal opportunity employer and does not discriminate on the basis of race, color, religion, citizenship, political activity or affiliation, marital status, age, national origin, ancestry, physical or mental disability, medical condition (as defined under California law), veteran status, sexual orientation, gender identity, gender expression, sex or gender (which includes pregnancy, childbirth, breastfeeding, or related medical conditions), taking or requesting statutorily protected leave, or any other basis protected by law. In addition, Caribou prohibits the harassment of any individual on any of the bases listed above or any other characteristics protected under federal, state, or local laws.

Direct applicants only. No agencies please.