Scientist (Protein Biochemistry- AUC, Light Scattering)

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

Summary
We are seeking a biophysical chemist to provide analytical protein characterization through the use of cutting-edge biophysical technologies in the Protein Biochemistry group at Regeneron. The qualified candidate will be responsible for providing in-depth biophysical and biochemical characterization of therapeutic proteins to support mid-late stage development programs. The candidate is expected to take on a leading role in applying a diverse array of advanced biophysical techniques to deepen our knowledge of late stage biotherapeutic proteins and their inherent heterogeneity to support regulatory application for commercialization.

Responsibilities

• Independently designs and conducts protein biophysical and biochemical experiments; analyzes data to elucidate quality attributes of therapeutic protein candidates and/or products.

• Provides biophysical support for both upstream and downstream functional groups; helps solve development problems in real-time.

• Takes a leading role in late stage development efforts to characterize size/charge variants, protein-ligand complexes, and high concentration protein solutions of therapeutic protein drug candidates.

• Documents experiments, results and findings in laboratory notebook; presents work at group and department meetings; contributes to drafting of analytical characterization reports, regulatory submission sections, and peer-reviewed articles for publication.

• May serve as a team representative in drug candidate-specific development team meetings, and share knowledge and expertise of biophysical chemistry at cross-function team meetings.

• May provide some assistance to Research Associates conducting research and developmental work.

• Participates in the general lab and instrument maintenance.
Requirements

• PhD in biophysical chemistry, molecular biophysics, or biochemistry with 0-3 years post-doctoral training in analytical protein characterization; experience in or collaboration with the biopharmaceutical industry an advantage.

• Demonstrated ability to apply a variety of biophysical techniques to study one or more of the following: protein-ligand complex formation, protein aggregation pathways, and/or high concentration protein solution dynamics.

• Demonstrated expertise in analytical ultracentrifugation (AUC), light scattering (static and/or dynamic), and spectroscopic (e.g. CD, fluorescence, FTIR, and/or Raman) principles and applications for analysis of proteins; working knowledge of NMR a plus.

• Extensive hands-on experience in performing and trouble-shooting size-based separation techniques, with a particular focus on AUC (sedimentation velocity / equilibrium) required.

• Experience with fluorescence correlation spectroscopy and/or field flow fractionation highly desired.

• Strong command of general protein folding, structure, and thermodynamics.

• High degree of proficiency in a variety of computer software for acquiring and analyzing light scattering, capillary electrophoresis, spectroscopic, and chromatographic data (e.g. ASTRA, 32 Karat, Empower).

• Excellent oral and written communication skills are required.

• A passion for science and innovation with a strong commitment to continual improvement and making significant contributions in a team environment.

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.