Scientist Immuno-Oncology

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

Summary
The Immuno-Oncology team is seeking a highly skilled scientist to contribute to the discovery and validation of novel therapeutic approaches aimed at harnessing the immune system to treat cancer. The successful candidate will design and execute preclinical in vivo experiments as well as advanced in vitro assays. The candidate will lead multiple projects in a fast-paced and results-driven environment. The candidate must be able to efficiently present her/his findings to internal multi-disciplinary teams and at external meetings.

Responsibilities

• Manage multiple projects simultaneously.

• Independently design, plan, and perform complex anti-tumor efficacy studies in mice including dosing (IV, SC, IP) and tumor growth monitoring.

• Dissection of tumors / organs for immune cell isolation and subsequent analysis.

• Design advanced flow cytometry (FACS) panels and perform FACS analysis on immune cells isolated from tumors and tissues.

• Analyze data using biological and statistical software such as Flowjo, Prism, Excel, etc.

• Collaborate closely with cross-functional teams across the company.

• Compile results across experiments and programs and present to multi-disciplinary teams, including translational teams, and senior management.

• Document experimental procedures and results in a well-organized fashion; generate experimental reports.

• Participate in general lab duties of the team.

• Continuously follow the current relevant literature, attend scientific meetings and maintain expertise in the field of Immunology and Immuno-Oncology

• Additionally, the successful candidate should be receptive to novel technologies to increase work efficiency, optimization of current protocols and development of new techniques.
Requirements:
This position requires a minimum of a PhD degree, with a minimum of 3 years of R&D experience in academic or industry (PhD study included). The qualified candidate will have a strong background in Immunology and/or Immuno-Oncology and will have hands on experience with techniques such as flow cytometry, cell culture, and mouse experimentation. Expertise in T cell and / or dendritic cell biology is highly desired. The candidate must be highly motivated and organized with efficient time management, attention to detail, and is expected to effectively and frequently communicate and collaborate with colleagues.

TECHNICAL SKILLS REQUIRED:
- Expertise with animal handling is a must; experienced in different methods of compound administration (i.v., i.p., s.c., etc), and tissue /sample collection.
- Ability to design and perform complex in vivo experiments utilizing tumor models in mice.
- Experienced in isolation and characterization of primary immune cells from murine tissues/tumors and human blood.
- Experienced in cell culture (both primary cells and established cell lines) and transfection; experience with viral transduction is a plus.
- Extensive knowledge and practical experience with advanced flow cytometry is a must, including complex panel design for cell surface and intracellular staining, data acquisition and analysis.
- Skilled in a variety of in vitro/ex vivo immune cell-based assays, including planning, execution, analysis and record keeping.
- Experience with recombinant lentiviral vectors and antibody technology or development is a plus.
- Experience with T cells, DC/macrophage-based functional assays is highly preferred.
- Experience with RNAseq and/or single cell RNAseq experimentation is highly preferred.

CORE COMPETENCIES:
- Expertise in cellular and molecular immunology
- Strong organizational and time-management skills including the ability to handle and prioritize multiple tasks simultaneously.
- Demonstrated creativity and independency.
- Ability to effectively collaborate as part of cross-functional teams.
- Clear and professional verbal and written communication.

This position will require a physical before starting.

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.