Scientist - Bioassay Development, Antibody Screening - Immuno-Oncology

Location
Tarrytown, NY, United States
Posted
Mar 21, 2019
Ref
15114BR
Required Education
Doctorate/PHD/MD
Position Type
Full time
Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

Summary
Are you the SCIENTIST we are looking for to join our dynamic Immuno-Oncology (I/O) bioassay team? Would you love to work in a highly innovative, inspiring environment - with unlimited resources and access to state of the art technologies? Do you love to collaborate within and outside your team? If yes, look no further, this is the position for you! Our group works on the development of highly complex bioassays for I/O, to be used in screening fully-human antibodies generated in our proprietary VelocImmuneTM mice. In cross-departmental meetings, we present and discuss our findings to our strong scientifically-driven senior leaders to move therapeutic drugs into clinic. What we really like about our bioassay team, is the energizing environment which drives us constantly to come up with better approaches and concepts. Therefore, your passion, your enthusiasm, your scientific curiosity to create challenging bioassays is needed to find new therapeutic drugs. The following requirements and responsibilities are required for you to complement our team:

The Bioassay group in the Therapeutic Proteins Department seeks a highly motivated and
energetic scientist with expertise in biological assay development to support screening and lead candidate selection. The ideal candidate should have a strong immunology background and thorough understanding of immune cell development and response to immune activating
stimuli. The successful candidate should possess a PhD with proven ability to successfully design, analyze, and troubleshoot bioassays, including but not limited to, engineered cell-based reporter assays, and primary cell activation assays.

Responsibilities
1) Isolate/process immune cells from human blood samples
2) Develop human primary cell-based functional assays
3) Develop cell-based functional assays using engineered-immortalized cells
4) Mammalian cell culture of adherent and non-adherent cell lines
5) Operate a variety of instruments including but not limited to HyperCyte, Accuri C6
cytometer, Cytoflex, ImageXpress micro XL, Victor, Hamilton, Envision Multilabel plate reader
6) Set up and run bioassays for screening and potency measurements
7) Provide Weekly presentations/verbal updates
8) Keep abreast of current/relevant literature in order to further develop scientific expertise and expand scientific/technical knowledge and skill sets

#LI-CB1
Requirements:
This position requires a PhD, and at least 2 years of related Postdoctoral/Industry experience. Candidates with a PhD, but no further postdoctoral experience would be considered at Associate Scientist level. Related experience should include:

1) Extensive knowledge and background in immunology
2) Expertise in handling/processing human blood samples
3) Proficient in immunofluorescence staining procedures and flow cytometry
4) Experience in primary cell activation/proliferation assays
5) Strong aseptic cell culture skills
6) Stable cell line engineering skills
7) Organized and thorough record keeping

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.