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Senior Associate Scientist - Pharmacokinetics and Drug Metabolism (PKDM)

Employer
Amgen
Location
Cambridge, MA, US
Start date
Mar 17, 2019

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Discipline
Science/R&D, Biotechnology, Pharmacology
Required Education
Masters Degree/MBA
Position Type
Full time
Hotbed
Genetown, Best Places to Work

Job Details

Amgen is seeking a Senior Associate Scientist to join the Pharmacokinetics and Drug Metabolism (PKDM) department at our Kendall Square site in Cambridge, Massachusetts.

In this role, you will join a motivated team of scientists contributing to Amgen's diverse discovery and development portfolio of therapeutic modalities with a focus on evaluating the absorption, distribution, metabolism and elimination (ADME) properties of small molecule therapeutic candidates. You will routinely interface with PKDM and therapeutic area colleagues across multiple Amgen research sites (Cambridge, MA, San Francisco, CA and Thousand Oaks, CA) to influence all stages of our drug discovery efforts, from early screening through IND-filing and beyond. In addition, the position will involve making innovative contributions to the fundamental understanding of drug biodistribution for small molecule and protein therapeutic modalities.

Core responsibilities of this position:
  • Conduct and optimize in vitro ADME studies that evaluate metabolic stability (microsomes and hepatocytes), protein binding (plasma and various tissue matrices), and drug-drug interaction potential (P450 inhibition and induction) of small molecule therapeutic candidates
  • Utilize appropriate cell culture techniques to support in vitro ADME, biodistribution (including use of microfluidic devices) and drug target characterization efforts
  • Perform mass spectrometry-based bioanalysis in support of in vitro ADME studies
  • Analyze, interpret and report preclinical ADME data

Beyond the core responsibilities, the successful candidate will have the opportunity to explore mechanistic inquiries into the fundamental physiological and biochemical factors that determine the ADME characteristics of small molecule and protein therapeutics. Interactions with colleagues in our multiple therapeutic areas or in the external scientific community will be highly encouraged.

Basic Qualifications

Master's degree and 3 years of research experience
OR
Bachelor's degree and 5 years of research experience

Preferred Qualifications
  • Master's degree in a pharmaceutical, chemical, or biological field of study
  • 5+ years of drug discovery and/or development experience
  • Expertise with implementing, optimizing and troubleshooting in vitro ADME assays
  • Experience with cell culture techniques
  • Working knowledge of multiple bioanalytical platforms (mass spectrometry) is a plus.
  • Critical thinking and demonstrated ability to effectively communicate with team members
  • Effective oral and written communication skills


Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing, and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology. Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world, and is developing a pipeline of medicines with breakaway potential.

Our culture is what makes Amgen a special place to work. We have a powerful shared purpose around our mission - to serve patients. We respect one another, recognize contributions, and have embedded collaboration, trust, empowerment and inclusion in all that we do.

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Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

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Company

We are all different, yet we have this in common: our mission to serve patients. This sense of shared purpose is key to our becoming one of the world’s leading biotechnology companies. It guides us as we continue to launch new medicines and reach millions of patients worldwide.

We live the mission.

We win together.

We thrive on continual challenge.

Our team of 22,000+ scientists and professionals worldwide bring distinct perspectives and experiences to all we do. We leverage our global talent to achieve together—to research, manufacture and deliver ever-better products and greater depth to our mission.

At Amgen, there is a strong correlation between our high level of diversity and performance. Because addressing issues with a wider range of perspectives and approaches leads to more creative problem-solving. Together, we’re transforming the promise of science and biotechnology into therapies that have the power to restore health.

Connect with us to explore how you can Win, Live, and Thrive at Amgen.

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Company info
Website
Phone
805-447-1000
Location
Corporate Headquarters
One Amgen Center Drive
Thousand Oaks
California
91320-1799
United States

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