Scientist I, Pharmacology
- Employer
- Pharmacyclics, LLC
- Location
- Sunnyvale, CA, United States
- Start date
- Mar 16, 2019
View more
- Discipline
- Science/R&D, Biotechnology, Pharmacology
- Required Education
- Bachelors Degree
- Position Type
- Full time
- Hotbed
- Biotech Bay
Job Details
More than 1,200 Pharmacyclics and AbbVie research scientists, clinicians, marketing, operations and corporate professionals work in the San Francisco Bay Area. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. Together, we are striving to outsmart cancer.
To learn more about us, please visit us at http://www.pharmacyclics.com/
The Preclinical Pharmacology Department is searching for a highly motivated Scientist I who will work collaboratively across Pharmacology/DMPK, biology and medicinal chemistry teams and generate efficacy and PD data to support preclinical development of drug candidates and regulatory submissions.
General Position Summary/Purpose:
Provide preclinical Pharmacology support to Pharmacyclics drug discovery and development projects in hematological malignancy and immune-oncology. Conduct efficacy/PK/PD studies. Investigate, develop, validate or optimize existing and new methods/models to solve project related scientific problems. Work closely with scientists in biology, medicinal chemistry, DMPK, and develop productive collaborations and communications with other groups across scientific disciplines.
Key Accountabilities/Core Job Responsibilities:
- Conduct tumor efficacy and PD studies.
- Understand and adhere to IACUC protocols regarding animal welfare and handling.
- Cell culture and banking to support efficacy studies.
- Conduct ex vivo assays such as MSD, WES, multi-color FACS, and Luminex to understand MOA of in vivo studies
- Commitment to scientific rigor, high data quality and careful documentation.
- Self-motivated, possess strong problem solving and organizational skills
- Ability to manage multiple responsibilities, adapt to changing priorities and meet deadlines in a fast-paced environment
- Attention to detail
- Excellent written and verbal communication skills
- Flexibility and motivation to learn techniques and accomplish goals outside those stated above
Qualifications:
- BS/MS in molecular biology, cancer biology, or pharmacology with >5 years of relevant research experience, preferably in a Pharmaceutical or Biotechnology industry setting
- Hands-on experience in mouse handling/bleeding, surgery, tumor studies, and tissue collection
- Extensive experience in MSD/WES/Luminex/ELISA and other Bioassays is required
- Technical experience in immunology, cell biology or molecular biology is a plus
- Competency with software programs, including MS Excel, Powerpoint, GraphPad Prism, FlowJo etc.
Equal Opportunity Employer Minorities/Women/Veterans/Disabled
Company
Pharmacyclics LLC, a wholly-owned subsidiary of AbbVie (NYSE: ABBV), is focused on developing and commercializing innovative small-molecule drugs for the treatment of cancer and immunemediated diseases. Pharmacyclics’ mission is to develop and commercialize novel therapies intended to improve quality of life, increase duration of life and resolve serious unmet medical needs. Pharmacyclics markets IMBRUVICA and has two product candidates in clinical development and several preclinical molecules in lead optimization. Pharmacyclics is committed to high standards of ethics, scientific rigor and operational efficiency as it moves each of these programs toward commercialization. To learn more, please visit www.pharmacyclics.com.
- Website
- http://www.pharmacyclics.com/
- Mini-site
- Pharmacyclics, LLC
- Phone
- 408-774-0330
- Location
-
995 East Arques Avenue
Sunnyvale
California
94086
US
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