Associate Scientist, Metabolic Diseases
Gilead seeks a highly motivated, creative and collaborative laboratory scientist to support discovery and development of therapeutic agents to treat non-alcoholic steatohepatitis (NASH) and other fibrotic diseases. The successful candidate will participate in discovery and translational research aimed at identifying and characterizing novel therapeutic targets, investigating the mechanism of action of therapeutics, and defining optimal drug combinations. The successful candidate will work within an established group focused on metabolic/fibrotic diseases and will be able to effectively interface with multidisciplinary project teams.
- Independently design/ develop, perform and manage experiments cell-based assays on cell lines and primary human cell cultures to support validation of novel therapeutics.
- Proactively troubleshoot technical issues and recommend potential corrective actions based on personal observations and literature searches.
- Presents results of work, interprets data, and draws conclusions regarding presented material and nature of work.
- Assess therapeutic potential and mechanism of action of new drugs by analysis of tissues and plasma from pre-clinical rodent models of fibrosis.
- Work with CROs to manage/ co-ordinate sample analysis and/or in vivo preclinical studies
- Acts as a resource for other employees within the department.
- Maintains familiarity with scientific literature and applies appropriately to research projects.
- Uses strong communication skills (both verbal and written) and interpersonal skills to communicate objectives and results.
Knowledge, Experience and Skills:
- 9+ years of experience with BS degree in a related scientific discipline.
- 8+ years of experience with MS degree in a related scientific discipline.
The candidate must have experience in using and understanding modern cell biology and pharmacology techniques including methods to evaluate cell signaling (western blot, immunoprecipitation), immunoassays (ELISA, MSD, Luminex), gene expression analysis, tissue analysis, in vitro CRISPR/Cas9 mediated gene knock-down/ knock-in, assays to assess substrate flux and mitochondrial function (such as Seahorse flux assays) etc. Extensive cell culture experience including human primary cell cultures (hepatocytes, stellate cells, fibroblasts, macrophages, adipocytes, etc) and/or development of various cell-based assays is required. Prior knowledge and research experience in metabolic disease including obesity, type 2 diabetes and NAFLD is strongly recommended. Prior experience performing interventional studies in preclinical species such as rat and mouse is a plus. Strong analytical and computer skills are required, including proficiency with basic data analysis programs (Excel, GraphPad Prism, etc.) and application of statistics. Applicants must have excellent communication skills (both verbal and written), and strong organizational and planning skills. The successful candidate must be able to manage more than one project at any given time, and work in a fast-paced, cross-functional and highly collaborative team environment.
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