Senior Scientist I/II, Immuno-Oncology

Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products - Imbruvica®, Venclexta™, and Empliciti™ - and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer.

AbbVie is expanding its oncology hub on the West Coast, with three sites in the San Francisco Bay Area (Redwood City, South San Francisco, and Sunnyvale) focused on the discovery and development of novel oncology therapies. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. This position will be based at AbbVie Biotherapeutics (ABR), AbbVie's Center of Innovation in Oncology Research and Development, located in Redwood City, CA. ABR R&D efforts focus on two key areas:

• Immuno-Oncology (I-O): developing therapeutics that activate the immune system to recognize and eliminate cancer cells
• Antibody drug conjugates (ADCs); antibodies conjugated to potent toxins for directed delivery to cancerous cells while sparing healthy tissues.
  ABR employs approximately 160 individuals in the San Francisco Bay Area. Its size and entrepreneurial work force allows for effective cross-functional collaboration, agility, and rapid decision making.

We are seeking a highly motivated individual to join AbbVie's rapidly expanding Immuno-Oncology group. The successful candidate will have expertise in T cell biology as well as cellular-based/chimeric T cell receptor-based therapeutics.

• This individual should have deep technical experience in immunology and oncology research with preferred experience in T cell biology including T cell receptors and peptide MHC antigens.
• This individual will be responsible for generating antigen-specific T cell clones, identifying and characterizing T cell receptors and engineering soluble T cell receptor-based therapeutics.
• This person will ensure scientific excellence, quality and completeness of key platform initiatives.
• The successful candidate will collaborate in a multidisciplinary research team in an exciting, fast-paced discovery-oriented environment.

• Ph.D. in Immunology or related major with typically 0-4 years (Senior Scientist I) or 4+ years (Senior Scientist II) of experience. Preference for some industry experience
• Demonstrated excellence and productivity in independent research.
• Extensive knowledge of T cell biology research.
• Excellent written and verbal communication skills are essential.
• Level commensurate with experience
• Practical experience in primary cell culture, T cell based assays, and with molecular biology techniques is required.
• Skills include, but not limited to: flow cytometry (FACs), PCR, qPCR, ELISA, Luminex, retroviral/lentiviral based transduction systems, T cell clone generation.
• Highly developed written and communication skills, and the ability to work in a highly collaborative team setting is essential.

Equal Opportunity Employer Minorities/Women/Veterans/Disabled