Eli Lilly and Company

Research Scientist-Protein Display/Engineering

Location
Greenfield, IN, United States
Posted
Mar 12, 2019
Ref
48691
Required Education
Doctorate/PHD/MD
Position Type
Full time
Elanco is a global animal health company that develops products and knowledge services to prevent and treat disease in food animals and pets in more than 90 countries. With a 64-year heritage, we rigorously innovate to improve the health of animals and benefit our customers, while fostering an inclusive, cause-driven culture for more than 5,800 employees. At Elanco, we're driven by our vision of food and companionship enriching life - all to advance the health of animals, people and the planet. Learn more at www.elanco.com.

Responsibilities
Position Description:

As a member of the Elanco Research Laboratories, this position will be responsible for designing and implementing a holistic veterinary antibody research platform that encompasses technologies to discover, engineer, and optimize therapeutic veterinary monoclonal antibodies. The position will require assessment, design, and implementation of a protein/antibody display platform that can be used across multiple projects. The incumbent will leverage contemporary and state-of-the-art technologies to minimize the hit to candidate timeline, while ensuring the right molecules are delivered the first time. This position will require routine interaction with senior scientists across multiple discovery and core research laboratories at Elanco. The incumbent scientist will be expected to support multiple projects at any given time. A strong foundation in molecular biology techniques and protein biochemistry will be required to proactively search for solutions in this discovery driven team.

Functions, Duties, Task:
  • Conceptualize, design, construct, and implement protein/antibody display platforms or similar systems for high to medium throughput functional screening of variants for affinity or thermostability optimization.
  • Conceptualize, design, construct, and implement methodologies for contemporary antibody discovery including single B-cell based approaches.
  • Conceptualize, design, construct, and implement platform(s) for the engineering (e.g, species-conversion, stability, effector function, expression, framework selection, LC/HC pairing) of biopharmaceuticals and, occasionally, vaccine antigens.
  • Develop vector sets and protocols for antibody engineering, including library design and construction, display platform optimization, panning/selection, and affinity determination.
  • Keep abreast of scientific literature in the field and implement novel modalities and protocols.
  • Provide expertise in evaluation of new platform technologies.
  • Proactively search for novel technologies or product opportunities and establish collaborations and research programs to deliver innovative technical solutions.
48691BR

Basic Qualifications
  • Minimum Ph.D. degree in a relevant scientific discipline (molecular biology, microbiology, cellular biology, or biochemistry)
  • 4 years of experience working on R&D projects in the human or animal health industries.
  • Qualified candidates must be legally authorized to be employed in the United States. Lilly does not anticipate providing sponsorship for employment visa status (e.g., H-1B or TN status) for this employment position.


Additional Skills/Preferences
  • Experience with protein/antibody display technology and/or automated high-throughput screening of protein/antibody variants.
  • Effective oral and written communications skills.
  • High personal ethical and quality standards.
  • Exceptional problem solving and decision-making skills.
  • Must be able to work productively in an interdisciplinary team environment
  • Proven project leadership skills
  • Demonstrated hands-on experience and knowledge of molecular biology techniques related to antibody/protein engineering including vector designs and display platforms
  • Knowledgeable in engineering novel functionalities into antibodies
  • Experience with analytical and developability assays/techniques for detailed antibody characterization


Additional Information
Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.