Senior Scientist I/II, CHO Cell Line Development

Worcester, MA, US
Mar 11, 2019
Required Education
Position Type
Full time
The Process Sciences Department at the AbbVie Bioresearch Center in Worcester, MA is seeking a highly motivated and experienced Senior Scientist to join the CHO Cell Line Development team. The Scientist will advance AbbVie's biotherapeutics pipeline through the development and characterization of highly-productive CHO cell lines suitable for cGMP protein manufacturing. The selected candidate will also have a major role in process optimization-focused on new methods and technologies that significantly enhance productivities and process efficiency. A strong candidate will have in-depth experience in CHO cell line development in the biopharmaceutical industry and demonstrated skills in process optimization and advancing projects both independently and as a member of collaborative, interdisciplinary teams. The position is based in AbbVie Bioresearch Centre, Worcester, MA.

Key Responsibilities Include:

  • Develop and characterize highly-productive stable CHO cell lines suitable for cGMP biotherapeutic manufacturing within project timelines.
  • Conceive, investigate and execute scientific research and development to continue process improvement activities to improve process efficiency, robustness and product quality; develop new methods, build technical expertise and intellectual property, and deepen scientific understanding.
  • Maintain a high level of productivity in the lab, with clear and accurate documentation
  • Mentor/supervise one or more scientists and evaluate their performance; be accountable for their effective performance, enhance team performance and to create a scientific climate of excellence to achieve business goals
  • Work collaboratively and cross-functionally on multiple projects with colleagues in Biologics/Discovery, Process Sciences, Manufacturing Sciences, CMC and others to meet team and company goals.
  • Proactively seek out new information and opportunities to advance our technologies and pipeline. Critically evaluate relevant scientific, regulatory and business advances and integrate this knowledge.
  • Contribute to the smooth and effective operation of the CHO cell line development labs.
  • Effectively present scientific data and concepts to internal and external audiences. Author and review technical reports, protocols and other key documents.
  • Understand and adhere to corporate standards regarding code of conduct, documentation, safety, appropriate handling of materials, and GxP compliance.

Position will be hired based on level of experience.

  • PhD in Molecular Biology or related discipline with 0-5 years of relevant experience in the biopharmaceutical industry (or M.S. degree with 8-10+ years relevance experience, Bachelor's Degree with 10-12+ years of experience).
  • Thorough practical and theoretical understanding of CHO cell line development to enable cGMP biotherapeutics manufactureing and associated areas of expertise (e.g., cell and molecular biology, gene editing, process development, recombinant protein production, protein characterization).
  • Excellent interpersonal and communication skills. Strong scientific curiosity with a passion for problem-solving and optimization.
  • Self-motivated with excellent attention to detail and ability to multi-task. Strong organizational, planning and trouble-shooting skills.
  • Skilled in using common software packages such as Microsoft Office
  • Demonstrated success in coordinating and executing important projects to achieve business unit goals.
  • Ability to work effectively in a highly collaborative and dynamic environment.


  • Proven track record in one or more of the following: CHO cell engineering, gene editing such as gene knock-out/knock-in, homologous recombination, targeted integration, DDPCR, and cell line genetic characterization
  • Supervisory experience a strong plus
Key Leadership Competencies:

  • Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance
  • Learns, fast, grasps the 'essence' and can change the course quickly where indicated
  • Raises the bar and is never satisfied with the status quo
  • Creates a learning environment, open to suggestions and experimentation for improvement
  • Embraces the ideas of others, nurtures innovation and manages innovation to reality

Equal Opportunity Employer Minorities/Women/Veterans/Disabled