Senior Research Associate

AveXis Inc.
San Diego, CA, US
Mar 08, 2019
Science/R&D, Research
Biotech Beach
Required Education
Bachelors Degree
Position Type
Full time

Ready to join a team committed to moving gene therapies into the clinical and commercial settings for patients and families devastated by rare neurological genetic diseases? AveXis is advancing cutting-edge science to treat rare and life-threatening genetic diseases starting with our clinical-stage, proprietary gene therapy candidate, AVXS-101 (ZOLGENSMA®). We are in the midst of an incredible journey and are looking for passionate individuals to join us on this important mission.

AveXis, Inc., a Novartis Company , is a clinical-stage gene therapy company, dedicated to developing and commercializing novel treatments for patients suffering from rare and life-threatening neurological genetic diseases. Our initial product candidate, AVXS-101, is our proprietary gene therapy product candidate currently in development for the treatment of spinal muscular atrophy, or SMA, Type 1, the leading genetic cause of infant mortality, and for the treatment of SMA Type 2. The U.S. Food and Drug Administration, or FDA, has granted AVXS-101 Orphan Drug Designation for the treatment of all types of SMA and Breakthrough Therapy Designation, as well as Fast Track Designation for the treatment of SMA Type 1. In addition to developing AVXS-101 to treat SMA Type 1 and Type 2, we also plan to develop other novel treatments for rare neurological diseases, including Rett syndrome (RTT) and a genetic form of amyotrophic lateral sclerosis (ALS) caused by mutations in the superoxide dismutase 1 (SOD1) gene.

AveXis is seeking an exceptional Senior Research Associate to join the dynamic and growing analytical team to establish analytical methods suitable for lot disposition and characterization of gene therapy drug products and substances. Under the guidance of his/her supervisor, he/she will help to develop, qualify/validate and transfer analytical methods for the characterization and lot release of gene therapy products. He/she will also help with drafting tech reports, SOPs and qualification/validation protocols and reports. The role will include routine laboratory work and general lab management (lab ordering, instrument maintenance, etc.).


  • Under supervision, help to develop, optimize and qualify/validate HPLC, CE, FFF based analytical methods suitable for gene therapy characterization, lot release and stability study.
  • Conduct routine lab work, including sample testing, making buffers, etc.
  • Help in analyzing and summarizing the test results and drafting tech reports and SOPs.
  • Serve as a general lab manager of analytical chemistry group in maintaining good lab environment, be responsible for general lab supply/reagent ordering, instrument maintenance/troubleshooting, sample management.
  • Proactively identify the needs of the analytical chemistry group and provide suggestions and solutions.


  • B.S. in analytical chemistry or related scientific discipline is required. 3-5 years of biopharma industry experience is required.
  • Good understanding and working knowledge of antibodies, vaccines or gene therapy drugs.
  • Good understanding and working experience with analytical techniques including but not limited to SEC, IEC, RPLC, CE-SDS, CIEF, spectroscopy.
  • Quick learner, highly motivated, hard-working and detail oriented. Strong ability to work in a fast-paced team environment with highly goal-oriented approaches and to prioritize work from multiple projects with can-do attitude is required.
  • Excellent written and verbal communication skills.

This position is located out of our La Jolla area facility and may require up to 10% travel between La Jolla, third party vendors (domestic) and our HQ and Manufacturing sites located in the Chicago area.

The level of this position will be based on the final candidate's qualifications.

Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities and activities may change at any time with or without notice.

AveXis is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, national origin, genetics, disability, age, sexual orientation or veteran status.