Bristol-Myers Squibb Company

Principal Scientist, Cancer Drug Discovery

Cambridge, MA, United States
Mar 07, 2019
Required Education
Position Type
Full time
This Principal Scientist position will join the Cancer Resistance Biology Research Team at Bristol-Myers Squibb in Cambridge, MA to lead preclinical drug development against therapeutic targets at the intersection of intrinsic tumor genetics and the extrinsic tumor microenvironment.


The qualified candidate is a highly motivated, interactive, and creative individual who possesses substantial experience in studying tumor biology and genetics, and experience or strong interest as to how these features impact immune responses to the tumor. The candidate will be an experienced program team leader and drug hunter. S/he will be an effective manager and mentor to more junior PhDs and associates. Since BMS is a matrixed organization, the candidate will be expected to effectively collaborate with colleagues in supportive line functions (including oncology, immuno-oncology and immunology, medicinal chemistry, candidate optimization and translational medicine) to advance preclinical development of therapeutic candidates to early clinical development. The successful candidate will demonstrate clear and professional verbal and written communication, capable of presenting scientific results to multidisciplinary teams, senior management and at external scientific meetings. The candidate will develop external partnerships/collaborations to advance internal programs, as appropriate. Similar they will be involved in the evaluation of partnering and other business development opportunities. S/he will be responsible for building and supervising a group of up to 2 PhD Investigators and 4-6 research Scientists/Associates. There will be less than 10-20% travel.

Qualifications Required

A Ph.D. degree with 8- 10 years of relevant industrial experience in cancer biology and genetics, immnuo-oncology or a closely related field

Industry experience with demonstrated abilities to drive preclinical development from target ID to clinical candidate selection, especially experience in small molecule drug discovery

A proven track record in the field of cancer biology and genetics, as evidenced by publication record

Demonstrated expertise to independently apply bioinformatics and data mining through multi-variate analysis; ability to effectively interact with core bioinformatics colleagues, as well as to use desktop tools/interfaces and public databases

Management/supervisory experience is essential.

Excellent oral and written communication skills, as well as the ability to effectively present scientific data and concepts to international standards.


Experience or the ability to innovate in novel preclinical in vitro , in vivo and ex vivo oncology model development that enables bridging from tumor biology to host immunity

Experience in studying the tumor stromal compartment

Ability to effectively interact with core bioinformatics colleagues, as well as with translational research scientists to generate testable hypotheses for targetable nodes that drive cancer resistance to current immuno-therapies.


1-2 PhD Investigators, 4-6 Research Scientists/Associates