Animal Lead Scientist - Immuno-oncology

Location
South San Francisco, CA 94080
Salary
Provide a good compensation package
Posted
Mar 02, 2019
Required Education
Bachelors Degree
Position Type
Full time

Animal Lead Scientist - Immuno-oncology and Antibody Discovery

South San Francisco, California

Apeximmune is a preclinical stage biotechnology start-up where we believe in harnessing the power of the immune system to treat and cure cancer. Based in South San Francisco, Apeximmune discovers and pioneers novel therapeutic antibodies that modulate immune cell activity to elicit durable, lasting efficacy in cancer and autoimmune disease. Our team integrates expertise in immunology, tumor cell biology, and protein biochemistry and engineering to provide therapies that can transform patients’ lives.

Apeximmune is seeking a talented scientist with a strong background in animal science to join our therapeutic antibody discovery team.  This position will lead an in vivo group to support pre-clinical animal efficacy studies.  You will be responsible for all aspects of the projects from high-level design to dosing, monitoring, tumor measurement, phenotyping, immunization and tissue harvest…etc.  The successful candidate will be highly skilled and experienced in all different routes injection and in tumor implantation.  In addition, you will utilize your knowledge and experience to make contributions to other ongoing projects.  There will also be opportunities to work together with other scientists to identify lead antibody candidates before moving them forward to animal studies.  Your work will be a critical component of Apeximmune’s strategic goals.

Key responsibilities include:

Independently leading an in vivo group including strategic planning, coordinating with vendors for mouse ordering and knockout mouse development, running experiments and analyzing results.  Working with other scientists to identify lead candidates, and ultimately define the path towards a go/no-go decision

Executing on and managing contract research organization-knockout mice characterization, in house husbandry and in vivo preclinical studies to ensure successful joint efforts

Actively collaborating within our team, including contributions to other projects, participation and presenting in internal meetings, and sharing your areas of expertise so that others can learn from your knowledge and experience

Keeping up-to-date with current scientific literature to help identify new targets or new strategies for existing targets

Requirements:

B.S. with 7+ years or MS with 5+ or Ph.D. with 2+ years of equivalent industry experience

Extensive experience with animal handling and injections including intraperitoneal, intravenous, subcutaneous, and footpad injections.

Expertise in syngeneic and/or transgenic mouse tumor models is a must.  Experience in the use and development of different tumor models and immunizations.

Proficiency in the isolation and characterization of lymph nodes, spleens and tumor infiltrating lymphocytes.

Experience in multi-color flow cytometry, alongside a deep knowledge of FACS-based phenotypic and functional characterization of immune cell populations is a plus.

Proficiency with basic data analysis software (GraphPad Prism, Excel, etc.)

Excellent written and oral communication, organization, and presentation skills

If you like the idea of creating new therapies that have a major impact on patients’ lives, of helping a new company rise off the ground, and of being part of a collaborative and talented team where everyone’s voice is valued, then this is the role for you.

Please send your resume.