Bristol-Myers Squibb Company

Research Investigator II - Separation Science

Princeton, NJ, United States
Mar 02, 2019
Required Education
Position Type
Full time
Bristol-Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases.

One shared journey is moving us forward at Bristol-Myers Squibb. Around the world, we are passionate about making an impact on the lives of patients with serious disease. Empowered to apply our individual talents and ideas so that we can learn and grow together. Driven to make a difference, from innovative research to hands-on community support. Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

The Discovery Chemistry team is looking for a hands-on analytical scientist to provide separation support for discovery of synthetic drug molecules in a team environment. The position will involve performing chromatographic separations for analysis and purification of synthetic molecules in a drug discovery environment, including the use of a variety of chromatographic and detection methods.

Primary responsibilities will include:
  • Performing chromatographic method development and analytical separation using HPLC, SFC, CE and GC, including maintenance and utilization of sophisticated parallel SFC and HPLC systems from a variety of vendors including Agilent, Shimadzu, and Waters.
  • Performing preparative scale separation of challenging drug molecules and metabolites using preparative-HPLC or SFC with UV and MS detectors from a variety of vendors including Agilent, Shimadzu, and Waters.
  • Use and maintain specialized separation and detection instruments that including2D UPLC/ToF MS; HPLC/Chemiluminescence Nitrogen Detector (CLND), UPLC/FLD, SEC/MALS/RI, and parallel SFC/UV/CD.
  • In addition, the chosen candidate will assist senior scientists to develop and implement innovative chromatographic and spectroscopic solutions for non-routine problems such as chiral interconversion kinetics and thermodynamics, biomarker assay development, and other special projects.


The candidate will have a Ph.D. in Analytical Chemistry or a related field with 1-3 years demonstrated experience in relevant biopharmaceutical applications.

The following qualifications are required or preferred:
  • Hands on experience in separation science is required, including both analysis and purification using HPLC and/or SFC with a variety of detection methods (UV and MS required).
  • Familiarity with chromatography instrument hardware and software from major vendors (Agilent, Waters and/or Shimadzu) with skills at diagnosis and correction of instrumental and methodological problems.
  • Familiarity with the concepts of modern chromatography, including method development, mobile and stationary phase selection, method optimization, and data interpretation is required.
  • Demonstrated ability to succeed in a highly matrixed multitasking environment, including time management and prioritization is required.
  • Evidence of using strong written and oral communication skills to effectively interface with customers and collaborators with diverse areas of expertise is required.
  • Hands-on experience in maintaining, automating and customizing chromatographic and spectroscopic instrumentation is desirable but not required.
  • Skills in computer programming, modeling and statistical analysis are desirable but not required.