Principal Scientist, Analytical and Formulation Development

Ambrx, Inc.
La Jolla, CA
Feb 28, 2019
Required Education
Position Type
Full time

Ambrx is a biopharmaceutical company enabling a new field of protein medicinal chemistry, using a fundamentally new technology that directs incorporation of amino acids beyond nature’s conserved set into biosynthetic proteins to produce high value biologics products. Ambrx is seeking a highly motivated scientist to be a key member of a fast-paced and dynamic organization.

The successful candidate will be a critical lead in the Analytical and Formulation Development group at Ambrx. As a senior member of this function, this individual should be able to maintain high standards of technical and quality excellence and will be involved in managing scientists and associates on a daily basis.


  • Lead a sub-group in developing analytical methods/assays ensuring that the projects are progressing as planned, process and products meet quality and regulatory requirements.
  • Work alongside the team to perform state-of-art analytical methods (mass spectrometry, peptide mapping including sequence variant, sequence liability and developability/manufacturability, and impurity characterization; disulfide mapping, glycan analysis, HPLC assays, CE, icIEF, biophysical assays etc.), formulation development, compatibility, forced-degradation, and stability studies.
  • Develop and apply new technologies for complex protein molecules (including E. coli and CHO derived proteins/antibodies) and conjugates for research, process development, and clinical development.
  • Oversee and perform assay development, qualification/validation and tech transfer to CMO/CRO to support clinical manufacturing, release and stability studies.
  • Write and diligently review development reports, SOPs, qualification reports, analytical protocols etc.
  • Provide expertise across functions in research, research transitioning to development and product development stages.
  • Leading efforts in protein and protein conjugates testing and characterization, significant experience with monoclonal antibodies, ADC, bi-specifics, and PEGylated proteins highly preferred.
  • Participate in project teams to provide analytical support and coordinate resources for new and ongoing projects, from research to clinical stages.


  • Ph.D. in Analytical Chemistry or related field with 10+ yrs of relevant industrial experience in analytical development and characterization for proteins.
  • Demonstrated leadership in staff and project management is required.
  • Essential hands-on experience and in-depth knowledge in instrumentation and modern analytical chemistry techniques (LC/MS/MS, peptide mapping, PTM characterization, HPLC assays, CE, biophysical assays etc.) is absolutely required.
  • Proven record in developing and applying new technologies for complex protein molecules, attention to detail in experimental design and data quality as well as excellent troubleshooting skills are required.
  • Extensive experience with assay development, qualification/validation and tech transfer to CMO to support clinical manufacturing. Prior experience in GMP-compliance and Quality/Regulatory Assurance is required.
  • Experience authoring CMC sections of IMPD/IND preferred.
  • Demonstrated ability to set clear and measurable goals for staff and prioritize tasks and resources to achieve superior work quality and efficiency.
  • Excellent oral, presentation, and written communication skills, be able to communicate effectively to senior management, corporate functions and collaborators.

To be considered as an applicant, please submit your resume/CV referencing the specific position of interest to Applicants whose qualifications and experience most closely match the requirements of the position will be reviewed. Candidates will only be contacted for evaluative discussions. Ambrx offers competitive compensation & benefits. EOE