Bristol-Myers Squibb Company

Hybridoma Leader / Associate Director Hybridoma (28)

Redwood City, CA
Feb 25, 2019
Required Education
Position Type
Full time
Hybridoma Leader

Hiring Manager: Antibody Generation Leader

We are looking for a highly motivated leader to lead the hybridoma effort within the Antibody Generation group. This is an exciting opportunity to make a significant impact within a department that is driving the biologics pipeline within BMS. The successful candidate is expected to evaluate novel antigen and immunization strategies and optimize the hybridoma workflow with an emphasis on utilizing recombinant methods to capture diverse antibody repertoires.

Major responsibilities:
  • Develop and optimize the existing hybridoma cloning workflow. Expand the scope of applications of hybridoma protocol and harmonize it with associated supporting automation and molecular rescue platforms.
  • Continue to refine hybridoma processes to generate leads from transgenic and wild-type animals.
  • Explore novel antigen design and immunization protocols.
  • Fully integrate NGS and recombinant antibody generation workflows in hybridoma group in collaboration with molecular rescue and assays group.
  • Be a champion in the lead discovery process and collaborate closely with biology project leaders to progress discovery projects
  • Excellent written and oral skills are necessary
  • Accomplish goals under project team timelines

  • Ph.D. in molecular biology or immunology with 6-8 years of industry experience or an advanced degree with 10+ years of relevant experience.
  • Significant experience in antibody generation techniques from hybridoma is required.
  • Experience with leading and developing teams of ≥4 FTE is required.
  • Proficiency in B-cell biology, antigen design, and immunization protocols is required.
  • Experience in analyzing humoral immune response using flow cytometry, HTRF, ELISAs is also required.
  • In-depth knowledge of antibody repertoire sequencing and data analytics is desirable.
  • Highly innovative and self-motivated.
  • Excellent time management and organizational skills.
  • Demonstrated ability to work in a multidisciplinary biologics discovery team.