Scientist l, CHO Cell Line Development

Employer
AbbVie
Location
Worcester, MA, US
Posted
Feb 25, 2019
Ref
1900650
Required Education
Masters Degree/MBA
Position Type
Full time
The Process Sciences Department at the AbbVie Bioresearch Center in Worcester, MA is seeking a highly motivated and experienced Scientist to join the CHO Cell Line Development team. The Scientist will advance AbbVie's biotherapeutics pipeline through the development and characterization of highly-productive CHO cell lines suitable for cGMP protein manufacturing. The selected candidate will have a primary role in the genetic characterization of CHO cell lines. A strong candidate will have in-depth experience in CHO cell line genetic testing techniques used in the biopharmaceutical industry and demonstrated laboratory skills in methods development. The position is based in AbbVie Bioresearch Centre, Worcester, MA.

Key Responsibilities Include:

  • Develop and/or characterize highly-productive stable CHO cell lines suitable for cGMP biotherapeutic manufacturing within project timelines.
  • Experimental design and bench experience with Southern blot, Northern blot, qPCR and ddPCR techniques.
  • Experience with vector design and construction and with sequence analysis software.
  • Experience in CHO cell line development and cell engineering/gene editing techniques including ZFN, CRISPR/Cas9 etc.
  • Author and review technical reports detailing genetic characterization protocols and results. Effectively present scientific data and concepts to various audiences.
  • Maintain a high level of productivity in the lab, with clear and accurate documentation of experiments.
  • Contribute to team performance and process improvement in a climate of scientific excellence. Work collaboratively on projects across multiple Process Science groups.
  • Proactively seek out new information and opportunities to advance our technologies.
  • Contribute to the smooth and effective operation of the CHO cell line development labs through our 5S program.
  • Understand and adhere to corporate standards regarding code of conduct, documentation, safety, appropriate handling of materials, and GxP compliance.


Position will be hired based on level of experience.
  • MS degree in Molecular Biology or related discipline with 0-2+ years of relevant experience in the biopharmaceutical industry, or Bachelor's Degree with 3-5+ years of experience.
  • Enable cGMP biotherapeutics manufacturing and associated areas of expertise (e.g., cell and molecular biology, genetic characterization, gene editing, process development, recombinant protein production).
  • Excellent interpersonal and communication skills. Strong scientific curiosity with a passion for problem-solving and optimization.
  • Self-motivated with excellent attention to detail and ability to multi-task. Strong organizational, planning and trouble-shooting skills.
  • Skilled in using common software packages such as Microsoft Office.
  • Ability to work effectively in a highly collaborative and dynamic environment.


Preferred:

  • Proven track record in one or more of the following: CHO cell line development, cell line genetic characterization, vector construction, gene editing such as gene knock-out/knock-in.


Key Leadership Competencies:
  • Builds strong relationships with peers and cross-functional team members.
  • Learns quickly, grasps the 'essence' and can change the course quickly where indicated.
  • Raises the bar and is never satisfied with the status quo.
  • Embraces a learning environment, open to suggestions and experimentation for continuous improvement.

At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer, we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.