Scientist / Senior Scientist - Protein Engineering

Job Title: Scientist/Senior Scientist
Department: Protein Engineering
Reports To: Associate Director

Summary:
Located in Redmond WA, Systimmune Inc. is a bio-pharmaceutical company focused on the treatment of cancer through developing novel therapeutic multi-specific antibodies, as well as antibody-drug conjugates (ADC's). Our objective is to create biologics that work through systematic intervention on the solid tumor micro-environment, to either directly attack the tumor and/or to activate the immune system to attack the tumor.

We are seeking a talented Scientist / Senior Scientist with extensive experience in antibody-based therapeutics, in Protein Engineering Department. The successful candidate will have a tracked record of antibody humanization, engineering, molecular biology, purification and characterization.

Essential Duties and Responsibilities:
• Lead and participate in antibody humanization and engineering for novel therapeutic multi-specific antibodies and Antibody Drug Conjugate (ADC).
• Responsible for cloning, expression and characterization of protein constructs
• Oversee CDR grafting, germlining and humanization
• Experienced with PTM site removal and optimization by structure-guided approach
• Evaluate signal peptides for CHO expression system and familiar with CHO expression vectors
• Responsible for candidate optimization, selection, and validation.
• Hands on in homology modeling, mammalian expression, surface plasmon resonance, flow cytometry, SDS-PAGE are required, HPLC is a plus
• Proficiency with Pymol, IgBlast, Discovery Studio, abYsis, Geneious are required
• Write and review Standard Operating Procedures (SOP)
• Support and closely work with other divisions to advance company goals
• Work with R&D and manufacturing department in China. Plan time to accommodate meetings and technical support with team members in China
• Participate in timeline planning and decision making regarding research priorities of company or department and provide information on feasibility of prospective projects.
• Other duties as assigned.

Qualifications:
To perform this job successfully an individual must be able to perform each essential duty satisfactorily. The requirements listed below are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Education & Experience
• PhD; MS; BS in Molecular Biology, Structural Biology, Biochemistry or a related field with 5+ years (PhD); 9+ years (MS); 12+ years (BS) of relevant academic and/or pharmaceutical or biotech experience
• Strong fundamental knowledge and experience in antibody humanization and engineering
• Extensive experience with homology modeling and structure-base mutagenesis

SystImmune is a stable, well-funded biotech company with a bright future. We offer an opportunity for you to learn and grow while making significant contributions to the company’s success. SystImmune offers a comprehensive benefits package including; 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 10 paid holidays and MORE.

SystImmune is an Equal Opportunity Employer. Interested applicants should send their CV and cover letter.