Associate Scientist I, Process Development

Worcester, MA, US
Feb 17, 2019
Required Education
Bachelors Degree
Position Type
Full time
We are currently seeking an Associate Scientist I, Process Development to join our team at the AbbVie Bioresearch Center in Worcester, MA. This position supports commercial and near-commercial protein purification manufacturing operations. The ideal protein purification manufacturing support engineer/scientist has both laboratory and manufacturing scale process support competencies. The candidate must be able to conduct laboratory scale experiments for process troubleshooting, optimization, and characterization. Commercial scale competencies include knowledge of protein purification unit operations. Responsibilities include providing on-floor support to Operations, troubleshooting, data entry, and CPV-compliant trending. Excellent written and verbal communication skills are essential.

Key Laboratory Responsibilities Include:
  • Execute experiments (e.g. resin lot evaluations for chromatography steps, chromatography characterization studies, UF/DF process optimization, impurity clearance studies, etc.)
  • Perform sample analysis (UV, HPLC, ELISA, etc.)
  • Assist in process optimization / continuous improvement activities
  • Interpret data accurately and independently, with supervisor input
  • Document work appropriately in electronic notebook
  • Write clear, concise and accurate reports, technical memos and presentations
  • Recognize and report experimental variances
  • Maintain and troubleshoot lab equipment and identify and implement lab optimization projects
  • Perform routine analytical methods
  • Follow established experimental protocols
  • Manufacturing support responsibilities:
  • Execute CPV-compliant trending program for commercial project(s): gather data from the manufacturing floor, enter/verify data in data trending systems, and assist in response to OOT and non-conforming events and other problems
  • Apply scientific/engineering principles to troubleshoot and improve processes
  • Develop technical proficiency with regard to assigned processes
  • Assist with implementation of continuous improvement projects

Position will be hired based on level of experience.

Educational Requirements:
  • Bachelor's Degree, or equivalent education.

Required Skills:
  • Excellent written and verbal communication
  • Practical knowledge of protein purification unit operations (chromatography, filtration and UF/DF)
  • Competent with Microsoft Office programs
  • Understanding of basic statistics

Preferred Skills:
  • Chromatography workstation experience (programming and running), esp. w/ AKTA / Avant
  • HPLC experience (running and peak integration), esp. w/ Agilent
  • Theoretical understanding of protein separation methods and DOE principles

Key Leadership Competencies:

  • Builds strong relationships with peers and cross functionally with partners outside of the immediate team to enable higher performance
  • Learns fast, grasps the "essence" and can change course quickly where indicated
  • Raises the bar and is never satisfied with the status quo
  • Creates a learning environment, open to suggestions and experimentation to drive the science in the field of interest
  • Embraces the ideas of others, nurtures innovation and manages innovation to reality