Scientist, Immunology of Gene Therapies

Location
Tarrytown, NY, United States
Posted
Feb 15, 2019
Ref
15425BR
Required Education
Doctorate/PHD/MD
Position Type
Full time
Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

Summary
We are seeking a creative and self-motivated scientist to join our team focused on novel therapeutics for genetic disorders, including lysosomal diseases. This person will investigate how the immune system responds to different gene therapy modalities and investigate methods to modulate those responses. This person will also contribution to the evaluation and development of novel gene therapy modalities and immunomodulatory agents.

Responsibilities

• Design and execution of both in vitro and in vivo experiments to investigate the immune responses to gene therapy vectors and cargoes

• Design and execution of both in vitro and in vivo experiments to investigate methods to modulate the immune response to gene therapy vectors and cargoes, including the design, construction, and testing of novel immunomodulatory agents

• Develop a deep understanding of the literature surrounding the area of focus, and stay up-to-date on the latest findings

• Communicate and present findings in intra- and inter-departmental meetings, meetings with senior management, at external conferences, in patents, and in scientific manuscripts

• Maintain accurate experimental records, including a detailed lab notebook updated in a timely and comprehensive manner

• Think critically and creatively about the scientific questions at hand and contribute to new innovation

• Work collaboratively with scientists and research associates throughout the company to drive the science forward

Requirements

• The candidate must have a PhD plus 2-5 years of experience

• Some experience working with animal models is essential

• A strong background in immunology is essential

• Familiarity with techniques such as molecular cloning, genome editing/CRISPR, cell culture, histology, ELISA, Elispot, Western blotting, flow cytometry, and confocal microscopy is highly desired

• Familiarity with enzyme replacement therapy, gene therapy, glycobiology, or lysosomal function/lysosomal disorders is a plus

• Excellent communication skills, both verbal and written, are required

• Ability to both work independently and collaborate with other scientists and research associates is essential

• Excellent publication record is highly desirable
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This position will require the individual to pass a physical before beginning employment.

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.