Immune Cell Biologist
We are seeking a highly motivated individual who will be critical for advancing major projects at Synthorx to facilitate the identification and evaluation of large molecule therapeutics for cancer and autoimmune diseases. The qualified candidate will develop and implement a variety of cellular assays to monitor the in vitro and ex vivo pharmacology of large molecule (biologic) leads at T and natural killer (NK) cell subsets. He/she will also play a key role in the design and implementation of read-outs for T cell function and immune toxicity (cytokine release, vascular leakage), including samples from in vivo studies, with minimal supervision. Additionally, will actively scout the pre-clinical and clinical literature, and patent records, in search for example molecules and study systems to test the pharmacological and safety properties of current and future targets in the Synthorx portfolio.The incumbent will join an interdisciplinary team of scientists and research staff validating novel targets for selection of future therapeutic antibody candidate development. The position will involve both management and bench-level activities, as well as cross-functional interactions with research teams focused on target validation and reagent generation for program development.
- Implement complex cellular assays (advanced multi-color flow cytometry for sorting and lymphocyte quantification, T cell stimulation, etc.)
- Culture and maintain cell lines and primary cells, for cell-based assays. Extensive experience with immune cells is a must
- Proficiency in the isolation and characterization of blood cell subpopulations employing cytometry and additional methods for immune cell analysis
- Manage mammalian cell stock inventory
- Coordinate with other lab members day-to-day lab activities including equipment maintenance, reagent orders, restocking consumables, etc.
- Develop appropriate assays to support analysis of large molecule pharmacology including Pharmacokinetics (ELISA) and cytokine (MSD) analysis of samples from in in vivostudies
- PhD in biomedical sciences
- 5+ years lab experience in Cancer Immunology or related field
- Experience with cell culture and aseptic technique is required
- Experience with multiparametric flow cytometry is required
- Experience with handling human tissue specimens (mostly blood) is a requirement, including the isolation of blood cell subpopulations
- Experience with advanced multi-color flow cytometry (FACS) for sorting and analysis of tissue-derived samples is a must
- Experience with animal models is a plus
- Familiarity with BSL-2 protocols and best-practices is a plus
- Experience training and managing lab members and overseeing projects is a plus
- Statistically analyzes data, draws conclusions from experimental results and has effective trouble shooting and problem solving skills.
- Candidates should have effective oral and written communication with group members and contract research organizations, must be self-motivated and highly organized, and able to work independently in a dynamic fast-paced research environment.