Scientist , Formulation Development

Location
San Diego, CA
Posted
Feb 12, 2019
Required Education
Doctorate/PHD/MD
Position Type
Full time

We are currently hiring a Scientist to join our Formulation/Process Development team. In this role, you will focus on the design, development, scale-up, manufacturing, and characterization of nucleic acid formulations to support an emerging research pipeline focused on treating rare diseases.

Responsibilities:

  • Design and develop nucleic-based formulations including complex nanoparticle formulations.
  • Process development, scale-up and technology transfer of multiple formulations, including supporting activities at CMO(s).
  • Perform formulation stability studies including but not limited to pilot stability studies with proposed drug product configuration, contact material compatibility and stability study, in-use compatibility study, accelerated stability studies, etc..
  • Prepare and characterize dose formulations for various in vitro and in vivo
  • Perform process-related investigations, identify root causes of process/manufacturing discrepancies, evaluate systems for trends and adverse findings, and implement appropriate steps to ensure process robustness.
  • Maintain proper documentation of all experimental procedures and results, including batch records, protocols, Standard Operating Procedures (SOPs) and other manufacturing related documentation.
  • Prepare technical reports and presentations which summarize procedures, study results, and data interpretation as needed.
  • Deliver high quality results in an accurate and a time sensitive manner.
  • Perform other activities per supervisor’s direction.

Requirements:

  • PhD (with 0-3 years of industrial experience) in Chemistry, Pharmaceutical Sciences, Biochemistry, Chemical Engineering, Bioengineering or other related field of science.
  • Experience with nucleic acid based formulations, complex/nanoparticle formulations, nucleic acid based formulation and working knowledge of tangential flow filtration (TFF – UF/DF).
  • Hands on expertise working with liquid, frozen, and/or lyophilized dosage forms.
  • Preferred qualifications include familiarity with stages of drug product development and cGMP concept, knowledge of analytical methods for testing lipid nanoparticles and understanding of the in vitro and in vivo experiments used for screening of nanoparticle formulation.
  • Must be highly motivated, well organized, an independent thinker with strong problem-solving skills, and pay great attention to details.
  • Comfortable working in a highly innovative and fast-paced environment and have a strong ability to cope with change.
  • Excellent verbal and written communication skills, great team player.

Arcturus offers relocation assistance for this role and a competitive compensation package commensurate with experience.

Arcturus is committed to equal opportunity and complies with all applicable national, state and local laws governing nondiscrimination in employment.

For more information about our company, visit www.ArcturusRx.com.

Job Type: Full-time

About Us:

Founded in 2013 and based in San Diego, Arcturus Therapeutics Ltd. is a publicly traded RNA medicines company. Arcturus’s commitment to the development of novel RNA therapeutics has led to partnerships with Janssen Pharmaceuticals, Inc., part of the Janssen Pharmaceutical Companies of Johnson & Johnson, Ultragenyx Pharmaceutical, Inc., Takeda Pharmaceutical Company Limited, Synthetic Genomics Inc., and Cystic Fibrosis Foundation Therapeutics Inc..

Our corporate culture is diverse, open and creative. We value collaboration and teamwork. We are looking for team members to grow with us and with a strong dedication to the highest levels of scientific excellence.

Arcturus is committed to equal opportunity and complies with all applicable national, state and local laws governing nondiscrimination in employment.

For more information about our company, visit www.ArcturusRx.com.