Process Development Senior Associate

Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading

independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.

The Pivotal Drug Substance Technologies organization at Amgen develops, characterizes and supports the commercialization of the drug substance manufacturing processes for all late-stage programs across the Amgen portfolio. Located at our Cambridge, MA site, this lab-based position will be responsible for support of the development, characterization, scale-up and support of upstream and downstream processes to enable commercial advancement of programs from Ph II/III clinical trials to marketing application. This role is in an integrated group in which cell culture and purification scientists work together to advance Amgen's rich, exciting and dynamic pipeline. With Amgen's biology first approach, the position provides the unique opportunity of being able to work on multiple modalities from antibodies and oncolytic viruses to bispecifics and siRNAs. The successful candidate will perform experiments at the bench scale to support purification process development operations. Considering the integrated design of the group, the candidate will also demonstrate the desire to expand and develop skills in both cell culture and purification. The candidate will apply established platform approaches and utilize problem-solving skills to rapidly solve day-to-day experimental challenges. Additionally, the candidate will utilize out-of-the-box thinking to contribute to technology development.

Basic Qualifications:

Master's degree or degree completed by May 2019

OR

Bachelor's degree and 2 years scientific experience

OR

Associate's degree and 6 years scientific experience

OR

High school diploma and 8 years scientific experience

Job Responsibilities:

• Perform bench-scale purification process development experiments to support both early and late stage process design activities.
• Apply established platform approaches and utilize problem-solving skills to rapidly solve day-to-day experimental challenges.
• Use JMP software to design DOE experiments and perform data analysis.
• Support tech transfer of processes to clinical and commercial manufacturing sites.
• Utilize out-of-the-box thinking and creativity to improve purification operations through the development and implementation of new technologies.
• Collaborate in a cross-functional team environment where both cell culture and purification development research is performed. Demonstrate the desire to expand and develop skills and expertise in both areas.

Preferred Qualifications:

• Bachelor's degree in Chemical Engineering, Biochemical Engineering, Life Sciences, or other relevant sciences and 2-3 years of purification development experience
• Master's degree in Chemical Engineering, Biochemical Engineering, Life Sciences, or other relevant sciences and 1-2 years of purification development experience
• Demonstrated ability to identify, develop and implement solutions to protein purification challenges through application of fundamental scientific and engineering principles, preferably in a process development environment
• Theoretical and practical understanding of protein chromatography and filtration
• Basic understanding cell culture principles; hands-on experience with mammalian cell culture techniques
• Motivated self-starter with excellent interpersonal and organizational skills
• Demonstrated success working with diverse team members in a dynamic, cross-functional environment
• Familiarity with design of experiments and statistical analysis of data

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

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