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Principal Scientist

Employer
Bristol Myers Squibb Company
Location
New Brunswick, NJ, US
Start date
Feb 9, 2019

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Discipline
Science/R&D, Biotechnology
Required Education
Doctorate/PHD/MD
Position Type
Full time
Hotbed
Pharm Country, Best Places to Work

Job Details

Job Responsibilities:

As Principle Scientist you will be responsible for developing and executing model based strategies for drug product development in preclinical and clinical programs. He/She will design and develop physiologically based pharmacokinetic absorption models to identify biopharmaceutics performance attributes that are critical for successful formulation and development of oral solid dosage forms. The position also requires developing integrated biopharmaceutics modeling and simulation packages for regulatory interactions and dossier submissions.

The successful candidate will be knowledgeable in pharmacokinetics, ADME, drug product formulation, materials science, biorelevant analytical methods, and regulatory guidance documents for oral dosage forms. This includes a proficient understanding of bioavailability/bioequivalence, formulation technologies (e.g. immediate release and controlled release tablets), materials characterization (e.g. physical forms, solubility analysis, etc.), as well as the numerous physiological factors important to drug absorption and pharmacokinetics. Additionally, the candidate will demonstrate ability to interpret and analyze clinical/pre-clinical pharmacokinetic data and have demonstrated experience with common software platforms (e.g. Phoenix WinNonlin, GastroPlus, simCYP). The candidate will be proficient in applying oral bioavailability enhancement formulation strategies (e.g. amorphous, solubilized, and other novel delivery systems) and establishing performance targets based on modeling and simulation.

This candidate must work in a matrix environment to apply modeling/simulation, pharmaceutics, ADME, chemistry principles and technologies to deliver robust products to patients. The successful candidate will effectively manage development projects with minimal supervision and provide independent interactions with multiple functional groups including discovery, clinical pharmacology, regulatory, and toxicology.

Job Requirements:

This position requires a Ph.D. in Pharmaceutics or related scientific disciplines with more than eight years of experience in biopharmaceutics and pharmacokinetic absorption modeling and simulation. In depth understanding of PBPK modeling software such as GastroPlus and SimCYP are a necessity. The candidate should have a demonstrated record of publications and presentations that apply mechanistic biopharmaceutics modeling. Hands on experience in NCE development, preformulation, and formulation supporting clinical progression of an asset is desired. The candidate must be innovative and possess excellent verbal and written communication skills as well as the ability to work effectively as an individual contributor in a team environment.

Company

Bristol Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases.

At Bristol Myers Squibb, we believe in the power of science to address some of the most challenging diseases of our time. Our focus on these unmet needs comes during a remarkable time, when unprecedented scientific breakthroughs are advancing the treatment of disease as never before in human history.

We work every day to transform patients’ lives through science. Each day, our employees around the world work together for patients – they are at the center of everything we do. They inspire us. They are the reason we come to work each day.

We combine the agility of a biotech with the reach and resources of an established pharmaceutical company to create a global leading biopharma company powered by talented individuals who drive scientific innovation.

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Company info
Website
Phone
+1-800-332-2056
Location
430 E. 29th St
14th Floor
New York
New York
10016
United States

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