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Functional Modeling Intern, Summer 2019

Employer
Regeneron Pharmaceuticals, Inc.
Location
Tarrytown, NY
Start date
Feb 8, 2019

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Job Details

The Regeneron Genetics Center (RGC) is a wholly-owned subsidiary of the Company, whose goals are to apply large scale human genetics to identify new drug targets and to guide the development of therapeutics programs and precision medicine. Building upon Regeneron's strengths in mouse genetics and genetics-driven drug discovery and development, the RGC specializes in ultra-high-throughput exome sequencing, large scale informatics and data analysis encompassing genomics and electronic health records, and translating genetic discoveries into new biology and drug discovery opportunities. The RGC leverages multiple approaches including large population based studies, Mendelian genetics and family based studies, founder population genetics, and large-scale disease focused projects and has developed a network of over 50 collaborations with research organizations around the world. Including some of the largest sequencing studies in the world, such as the DiscovEHR study in collaboration with Geisinger Health System, and an initiative to sequence 500,000 participants with the UK Biobank, the RGC has built one of the largest human genetics databases, including sequence data from over several hundred thousand participants and rapidly growing. Our interests encompass a breadth of different areas across all therapeutic areas and the RGC is highly integrated into all facets of research and development at Regeneron. Program goals include target discovery, indication discovery, and patient-disease stratification. Objectives include advancing basic science around the world through public sharing of discoveries, providing clinically-valuable insights to physicians and providers of collaborating health-care systems, improving patient outcomes, and identifying novel targets for drug development.

These positions are in Functional Modeling in Tarrytown, NY. There are 3 openings for Summer 2019. Each opening is described below.

Position 1:
This student will support on-going projects to develop and test in-vitro cell culture models of human disease gene variants resulting mainly in metabolic disorders. The project will involve mainly cloning of variants, cell culture work including standard cell lines and terminally differentiated pluripotent stem cells. Preferred candidate will possess background in molecular and cell biology, biochemistry.

Position 2:
The student will engage in the research activities of the RGC-Functional Modeling group. They will shadow his/her supervisor during the activities in the Vivarium, where the student will observe the use of mice - in which RGC-indentified gene variants have been generated - in experiments of inflammatory bowel disease modeling and participate to the data analyses.
The student will actively perform in vitro assays to characherize own the above mentioned variants affect the function of the mutant proteins: specifically, the student will (1) run site-directed mutagenesis to generate cDNAs encoding for the RGC-identified variants, (2) express wild-type and mutant constructs in cells to assess the proteins' expression level and sub-cellular localization through Western blot and immuno-fluorescence and (3) test whether the mutant proteins are impaired in binding to known partners through immuno-precipitation.

Position 3:
The student will study the role of zinc in skeletal biology. Zinc is an essential trace element and regulates many key biological processes including development, growth and immune function. Zinc supplementation has been shown to increase bone mass and prevent osteoporosis. As effectors of both osteoblast and osteoclast formation and activity, Zinc has a complex role in the skeleton. In this project, the student will examine the effects of Zinc in skeleton in mouse models, and explore the Zinc signaling pathways in its responsive cells in bone.

Start building your skills at Regeneron.

• Position 1: Must be a graduate student; Position 2: Can be an undergraduate or graduate student; Position 3: Must be an undergraduate student

• Must be pursuing a degree in Molecular or Cellular Biology, Biochemistry, Genetics, Bioengineering, Chemistry, or related field

• Position 1: Must have experience with performing routine culturing and cloning of mammalian cells; design, execute, and control experiments according to protocols; perform laboratory calculations and manipulations independently.

• Position 2: Must have experience with basic Molecular Biology laboratory techniques

• Position 3: Must have experience with cell culture, RNA/Protein extraction, qPCR, WB, histological analysis, data analysis (Excel, GraphPad); Experience in skeletal research is preferred

• Must be motivated, eager to learn, and a good team player

General Intern Program Information:

• Must be enrolled in, or accepted to, an academic program pursuing a Bachelor's, Master's, PhD or PharmD

• Summer Program is full-time (~40 hrs/wk) for at least 10 weeks and is paid

• Prefer demonstrated leadership in areas such as campus activities, clubs, sports or the community

• Minimum GPA of 3.0

• You will work with a specific manager on a project(s)

• Enjoy weekly 1 hour Intern Program events: learn about other areas of the company from VPs and other employees, soft skills workshops, networking, volunteering, and more!

• Present to your team on your summer project

Transportation and Housing:

• A free shuttle is offered from the North White Plains or Tarrytown train stations to the Tarrytown campus

• Get to know other incoming Interns on our closed LinkedIn page when you accept an offer

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

Company

Regeneron is a leading biotechnology company that invents life-transforming medicines for people with serious diseases. Founded and led for 30 years by physician-scientists, our unique ability to repeatedly and consistently translate science into medicine has led to seven FDA-approved treatments and numerous product candidates in development, all of which were homegrown in our laboratories. Our medicines and pipeline are designed to help patients with eye disease, allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, infectious diseases, pain and rare diseases.
 
Regeneron is accelerating and improving the traditional drug development process through our proprietary VelociSuite® technologies, such as VelocImmune® which produces optimized fully-human antibodies, and ambitious research initiatives such as the Regeneron Genetics Center, which is conducting one of the largest genetics sequencing efforts in the world.

Stock Symbol: REGN

Stock Exchange: NASDAQ

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Company info
Website
Phone
914-847-7000
Location
Corporate Headquarters
777 Old Saw Mill River Road
Tarrytown
New York
10591
United States

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