Scientist

Regeneron Pharmaceuticals, Inc. is seeking a Scientist for our Tarrytown, New York location to independently conduct experiments and serve as the lead for pre-clinical development of therapeutic targets in immunology and molecular biology; troubleshoot methodological and technical issues, interpret experimental data and literature, and communicate results to supervisor, department, or project team. Help create a safe, effective, collaborative and efficient working environment. Contribute to therapeutic target advancement by developing new methods or technologies and troubleshooting. Develop and optimize relevant disease mouse models for drug/antibody candidates and subsequent analysis of associated disease-related pathologies by flow cytometry, histology, microscopy and ELISA. Develop and execute cell-based assays to screen candidate antibodies for various research programs. Perform ELISAs and or MSDs to measure cytokine levels and determine antigen binding for various research programs. Perform in vitro experiments on isolated immune cells, analyze data and present to supervisor and team.

Qualified applicants will have a PhD degree in Molecular Microbiology, Immunology, or a related field and 8 years of experience in a laboratory setting, of which two years must be post-doctoral industry experience in immunology. Applicants must possess 8 years of experience with the proper handling and care of mice, general surgical techniques, and the collection of blood and tissue samples; and with tissue culture and in vitro cell based assays. Must possess 6 years of experience with functional cell-based assays and ex-vivo cellular analysis; conducting studies with multicolor flow cytometry on LSRII and/or LSRFortessa machine; and 5 years of experience with molecular biology experience, including DNA and RNA isolation, QRT-PCR, WesternBlot, immunoprecipitation, protein purification, cloning and lentiviral transduction. Must possess 3 years of experience analyzing biological samples on FloJo, FACSdiva, GraphPad Prism, Adobe Photoshop and/or illustrator, Agilent 2100 Bioanalyzer, Galaxy, Halo, Softmax Pro, and Image J; and research experience working In collaborative, cross functional teams and must be proficient in recording data in electronic notebooks that will be used for FDA and Patent filings. 2 years of experience with allergy and autoimmune disease models, and subsequent analysis of associate disease-related pathologies by flow cytometry, histology, microscopy, ELISA, and meso scale discovery (MSD) platform. 2 years of experience TH2 mediated diseases, allergy and asthma models, infectious disease models B-cell and plasma cell biology; with high-throughput screening systems, including 96-Well liquidator, aquamax microplate washer, spectramax plate reader and benchsmart 96-Well high-throughput platforms, and animal tissue processing with gentlemacs OCTO dissociator; fluorescence microscopy; developing and optimizing mouse models; processing and preparing samples/libraries for single cell and bulk RNA sequencing, DNA sequencing and ribosome profiling; sort different immune cells and perform cytospin phenotyping analysis. Record of publications in peer-reviewed journals, record of presentations at national and international meetings and experience with teaching/ monitoring. Up to 10% international and domestic travel is required.

To apply for this position, please submit your resume, indicating Requisition Code 15249BR to:
George Peterson
Regeneron Pharmaceuticals, Inc.
777 Old Saw Mill River Road
Tarrytown, New York 10591

#LI-DNI

#GD-DNI

#IN-DNI