Research Scientist, Biophysics
Gilead is seeking a motivated researcher to work in the Biophysics group within the Research organization. The successful candidate will support discovery projects with development and execution of biochemical assays to measure protein activity, oligomeric state and protein-ligand interactions using techniques such as UV-Visible and fluorescence spectroscopy, analytical ultracentrifugation and calorimetry. The candidate must be motivated driven, creative, and able to work independently, and must display scientific rigor. The candidate will be required to select appropriate experimental approaches to address scientific questions. Responsibilities will include development and troubleshooting of protein activity and protein-ligand binding assays, data analysis and management, writing reports and SOPs, and presentation to project teams and senior leadership. The successful candidate will work in a team environment and will need to communicate effectively.
Essential Duties and Job Functions:
The successful candidate will work as a member of Biophysics in Gilead’s Biology Core Support group. Under general supervision, the successful candidate will provide experimental support for multiple drug discovery programs. Duties will include design and critical analysis of experiments aiming at characterization of oligomeric state of proteins and protein-ligand binding interactions, using biophysical techniques such as fluorescence and absorbance spectroscopy, analytical ultracentrifugation, calorimetry (ITC, DSC), and kinetics. In addition, responsibilities will include assay development and optimization, mechanism-of-action studies, presenting work at group meetings, preparing data for others to present, shared responsibility for maintenance of laboratory equipment and laboratory space, and compliance with EH&S regulations. The candidate will work in a multidisciplinary environment on scientific problems with moderate to high complexity, will interact with researchers in other Research Groups, and is expected to work effectively with other members of a team. The candidate is also expected to document experiments in a thorough and timely manner. Attention to details and skills in troubleshooting of experimental design and results are essential.
Knowledge, Experience and Skills:
The candidate should possess a Ph.D. in Chemistry, Biochemistry, or Biology with 0+ years industry experience, or a B.Sc. or M.Sc. degree with extensive academia or industry experience and track record of positive impact on project goals. The candidate should have basic knowledge of kinetics and thermodynamics, and the ability to plan and perform experiments with minimal supervision, within timelines, and in alignment with the objectives of ongoing research projects. Skills should include the ability to operate complex scientific equipment, select appropriate methods and techniques to perform experiments, analyze data and prepare detailed reports. The candidate should be able to independently recognize anomalous results , interpret experimental outcomes, and have practical knowledge of data analysis tools. The candidate is expected to participate and present data at group and project meetings. The candidate should be highly motivated, interested in seeking scientific and personal development, and keen to learn and apply new technologies. Experience using ITC and DSC will be advantageous, although candidates with a strong biophysical understanding of other techniques to study protein-ligand interactions are also encouraged to apply. Excellent verbal communication skills and interpersonal skills are required.
As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact email@example.com for assistance.