Principal Scientist

Location
Marlborough, MA, United States
Posted
Feb 01, 2019
Ref
904912
Hotbed
Genetown
Required Education
Bachelors Degree
Position Type
Full time
Purpose of the Position:

The Principal Scientist is responsible for meeting the analytical testing requirements to support research and development projects primarily focused on oligonucleotides.

Key Job Responsibilities:
  • Supervise/manage staff as needed
  • Lead the design of testing per method or protocol for development, qualification, verification, validation, and transfer of analytical methods for multiple projects simultaneously
  • Analyze and review project data, correct errors, and report results for multiple projects to support research and development primarily focused on oligonucleotides
  • Author and approve scientific and regulatory documentation
  • Lead and perform GDP, technical, and gap analysis review and investigations across multiple projects
  • Provide professional scientific leadership in all internal and external interactions
  • Monitor laboratory compliance
  • Design, review, and improve method development strategies
  • Champion and implement new and innovative analytical applications and technology
  • Provide advanced-level training internally and externally
  • Plan, track, execute, and review multiple project team tasks to deliver project results on time
  • Exercise latitude in determining objectives and approaches to critical assignments
  • Communicate with clients and directly resolve issues
  • Interview candidates and advise on hiring, improvement plans, and promotions.
  • Develop and lead inter-department objectives for continuous improvement and technical excellence
  • Advise clients on analytical scope to meet technical and regulatory requirements
  • Review BD customer proposals and represent department in customer-facing meetings
  • Mediate personnel conflicts within the group and promote a positive work atmosphere

    Job Knowledge Required:
  • BA/BS/MS with 15+ yrs. of related experience or PhD with 10+ yrs. of related experience
  • Subject matter expert analytical chemistry knowledge including theory and application of three or more chromatographic and spectroscopic techniques for identification, purity, and assay of various analytes
  • Operate and troubleshoot available instruments including HPLC and MS
  • Review and approve outsourced method development and validation
  • Application of chemistry and oligonucleotide knowledge to method development and solving complex problems independently
  • Fundamental scientific knowledge of chromatography, spectroscopy, and spectrometry methods
  • Advanced Word, Excel and PowerPoint
  • Review and correct advanced algebraic and statistical calculations
  • Proficient in technical writing and represents Avecia to the oligonucleotide community through technical presentations and publications
  • Author, revise, and approve SOPs
  • Competency to think strategically and conceptually to apply quality by design principles when designing experiments
  • Perform method gap and error analyses
  • Knowledge and application of cGMPs and regulatory guidance documents
  • Application of oligonucleotide chemical and physical property knowledge to develop new methods to characterize oligonucleotides
  • Remain abreast of emerging analytical technologies in the oligonucleotide field

Equal Opportunity Employer