Research Associate, Antibody Generation (29)
- Employer
- Bristol Myers Squibb Company
- Location
- Redwood City, CA, US
- Start date
- Jan 26, 2019
View more
- Discipline
- Science/R&D, Research
- Required Education
- Associate Degree
- Position Type
- Full time
- Hotbed
- Biotech Bay, Best Places to Work
Job Details
We are seeking a Research Associate with hands-on experience in antibody discovery using hybridoma and/or B-cell approaches to support therapeutic biologics programs and reagent antibody generation. Responsibilities will include executing on all steps of the antibody generation process. This includes preparing immunization, hybridoma fusions, screening and sequence analysis of antibodies.
Responsibilities
- Contribute to antibody discovery goals utilizing hybridoma and molecular biology approaches.
- Participate in designing antibody generation strategies including immunogen design and screening cascades.
- Execute on all stages of antibody generation, including scheduling and preparing immunizations, hybridoma fusion and culture, screening of antibodies and hybridoma expansion for sequencing and antibody purification.
- Contribute to antibody sequence recovery through PCR and sequencing workflows, followed by sequence analysis.
- Execute binding screens using ELISA, flow cytometry, or HTRF assays. Experience in high-throughput approaches and/or automation is a plus.
- Trouble-shoot and optimize protocols and propose creative solutions to improve efficiency to existing processes.
- Prepare detailed and thorough analysis of data and present updates to managers and project teams.
- Maintain detailed records of all experiments in ELN and using in-house databases and tracking systems.
- Communicate with multiple functional areas (e.g. Automation, Proteins groups) as well as project teams to coordinate antibody generation efforts.
- Keep up to date on current protocols and methods for antibody generation and propose new ideas to improve in-house processes.
Qualifications
- BA/BS in Biology, Immunology, or related field with 5+ years' experience.
- Experience with antibody generation using hybridoma and/or B-cell approaches is required.
- Extensive experience with mammalian cell culture and sterile techniques is required.
- Strong experience with antibody binding assays, especially ELISA and multi-color flow cytometry is required.
- Experience with molecular biology techniques including RT-PCR, 5'RACE and sequence analysis (VectorNTI, Geneious) is required.
- Expertise in Excel, Graphpad Prism, and flow cytometry analysis software is required, Spotfire experience is a plus.
- Understanding of the requirements for therapeutic antibodies properties is a plus. Previous industry experience is a plus.
- Strong focus, motivation, and commitment to hands-on lab work is required.
- Excellent organization and communication skills.
Company
Bristol Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases.
At Bristol Myers Squibb, we believe in the power of science to address some of the most challenging diseases of our time. Our focus on these unmet needs comes during a remarkable time, when unprecedented scientific breakthroughs are advancing the treatment of disease as never before in human history.
We work every day to transform patients’ lives through science. Each day, our employees around the world work together for patients – they are at the center of everything we do. They inspire us. They are the reason we come to work each day.
We combine the agility of a biotech with the reach and resources of an established pharmaceutical company to create a global leading biopharma company powered by talented individuals who drive scientific innovation.
- Website
- http://www.bms.com/
- Phone
- +1-800-332-2056
- Location
-
430 E. 29th St
14th Floor
New York
New York
10016
United States
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