Senior Scientist, Biology

About Principia:

Principia Biopharma is a clinical-stage biopharmaceutical company dedicated to bringing transformative oral therapies to patients with significant unmet medical needs in immunology and oncology. Principia’s proprietary Tailored Covalency^® platform enables the Company to design and develop reversible and irreversible covalent, small molecule inhibitors with potencies and selectivities that have the potential to rival those of injectable biologics, yet maintain the convenience of a pill. PRN1008, a reversible covalent BTK inhibitor, is being evaluated in a Phase 3 clinical trial in patients with pemphigus, an orphan autoimmune disease, and in a Phase 2 clinical trial in patients with immune thrombocytopenic purpura, a rare hematological disease.  PRN2246, a low dose covalent BTK inhibitor which crosses the blood-brain barrier, is being developed for multiple sclerosis and, potentially, for other diseases of the central nervous system.  It has completed dosing in a Phase 1 clinical trial in healthy volunteers and has been partnered to Sanofi. PRN1371, a covalent inhibitor of Fibroblast Growth Factor Receptor, or FGFR, is being evaluated in a Phase 1 trial in patients with solid tumors.

Job Description:

• Senior scientist role in biology, with a strong focus on drug discovery in immunology
• Identify and implement preclinical studies (in vitro/in vivo) to explore target biology, preclinical differentiation and mechanism of action; translate research discoveries into clinical drug programs
• Contribute to assessment of new therapeutic targets, act as discovery target champion and/or research project leader
• Oversee and execute cellular assays and manage CRO and collaborator studies; may directly or indirectly supervise activities of laboratory personnel

Abilities:

• Deep understanding of immunology
• Experience in small molecule drug discovery with a focus on preclinical mechanism of action and cellular biology desired; clinical PD/biomarkers translational expertise is a plus
• Solid foundation in relevant models and cellular techniques, with hands-on experience and skills
• Ability to interpret and report results, present findings internally and externally
• Capability of evaluating scientific literature to stay current within field of research
• Proficiency in software for analyzing data, such as Prism, Excel, FlowJo or other relevant scientific applications is required
• Demonstrated talent to work effectively with colleagues from diverse disciplines to advance drug discovery programs; experience working with external CRO’s and academic collaborators is a plus

Minimum Qualifications:

• PhD or equivalent in immunology, haematology or related areas with relevant post-doctoral  training
• 3+ years Biotech / Pharma industry experience

Principia Biopharma is an equal opportunity employer