Sr. Research Associate/ Research Associate, Biology

About Principia:

Principia Biopharma is a clinical-stage biopharmaceutical company dedicated to bringing transformative oral therapies to patients with significant unmet medical needs in immunology and oncology. Principia’s proprietary Tailored Covalency^® platform enables the Company to design and develop reversible and irreversible covalent, small molecule inhibitors with potencies and selectivities that have the potential to rival those of injectable biologics, yet maintain the convenience of a pill. PRN1008, a reversible covalent BTK inhibitor, is being evaluated in a Phase 3 clinical trial in patients with pemphigus, an orphan autoimmune disease, and in a Phase 2 clinical trial in patients with immune thrombocytopenic purpura, a rare hematological disease.  PRN2246, a low dose covalent BTK inhibitor which crosses the blood-brain barrier, is being developed for multiple sclerosis and, potentially, for other diseases of the central nervous system.  It has completed dosing in a Phase 1 clinical trial in healthy volunteers and has been partnered to Sanofi. PRN1371, a covalent inhibitor of Fibroblast Growth Factor Receptor, or FGFR, is being evaluated in a Phase 1 trial in patients with solid tumors.

Job Description:

• Senior research associate (SRA) or research associate (RA) in biology
• Responsible for development and implementation of novel cell-based assays for characterizing the potency of small molecule inhibitors
• Individual will also perform cellular mechanism of action studies
• Position requires organizing, coordinating, and executing laboratory functions and project assignments
• Candidate will be expected to work effectively with colleagues from diverse disciplines and to present experimental findings to others

Abilities:

• Cell biology expertise with knowledge of techniques associated with setting up and executing cell-based assays and culturing both primary cells and cell lines
• Experience with cellular methods to evaluate small molecule inhibitors
• Familiarity with utilizing 96/384-well formats
• Hands-on experience in the areas of immunology and/or inflammation is highly desired
• Experience with the following techniques is sought: flow cytometry, ELISAs, western blot analysis, cell proliferation, protein assays, TR-FRET, and Alphascreen
• Knowledge of software for analyzing dose-response data, such as Prism and Excel, and of creating presentations in PowerPoint
• Candidate must have a capability of reading and evaluating the scientific literature to aid in novel assay development

Minimum Qualifications:

• Training should include a BS or MS in biology, cell biology, immunology, or related areas
•  5+ years (SRA position) or 2+ years (RA position) Biotech/Pharma industry experience in small molecule drug discovery

Principia Biopharma inc. is an equal opportunity employer.