Assay Development Scientist, Antigen Map

Seattle, Washington State
Base, Bonus, Options
Jan 23, 2019
Required Education
Position Type
Full time

Position Overview:

The Antigen Map is a collaborative project between Adaptive Biotechnologies and Microsoft to understand the relationship between T cell receptor sequences and antigen specificity. This team is hiring an experienced assay development scientist to assist with the development and optimization of production-ready cellular assays that link antigen specificities to specific TCR sequences. Under minimal supervision, the assay development scientist will be expected to design and perform experiments that will develop robust, reproducible and high through-put, production-ready laboratory assays from research proof-of-concept studies. The scientists will also organize and analyze results and communicate and present findings in team meetings.

Job Responsibilities:

  • Design and execute experiments that develop and characterize cell-based assays Efforts may include:
    • Finding optimal conditions for primary human cell culture
    • Characterizing variance and stability of assays at scale
    • Identifying and developing controls for sources of variability
    • Boundary testing
    • Identifying and testing areas for process improvements
    • Modeling and testing workflows
    • Developing and testing Quality Control metrics and Quality Assurance practices
  • Support technology transfer to production environment
  • Effectively work and communicate with group members and other groups in a dynamic and fast paced environment in order to accomplish goals
    • Analyze and report data to senior staff both informally and through formal reports and presentations
  • Serve as a subject matter expert for process engineering


Experience and Skills:

  • PhD in relevant scientific discipline
  • 5+ years lab experience in Immunology, assay development for production processes, or related field, with a familiarity with immunological assays
  • Prior role in technology transfer to a production environment (industry experience)
  • Experience with cell culture is required
  • Experience with multiparametric flow cytometry is required
  • Experience with assay development, optimization and Design of Experiments (DOE)
  • Ability to perform statistical analyses of experimental results
  • Expertise in culture scale-up and optimization is highly desirable
  • Experience with handling human tissue specimens (blood, etc.) is a plus
  • Excellent communication skills