Director, Clinical Biomarkers - Oncology

The Oncology Clinical Biomarker Group is responsible for developing and executing on translational strategies for furthering the development of the industry-leading BMS Oncology and Immuno-oncology pipeline. Bristol-Myers Squibb is actively conducting translational medicine research to further our understanding of cancer biology and to identify which patient populations may be more likely to derive benefit from Immuno-Oncology (I-O). Bristol-Myers Squibb has long believed the future of cancer research is dependent on investments in science and partnerships. Collaboration is integrated into our organizational framework across Translational Medicine and R&D. The Clinical Biomarker Scientist (Director) is responsible for developing and executing on translational strategies for the Oncology pipeline. This scientist works on various projects in either early or late drug development and will act as a key interface with the Translational Medicine Team Lead.

The successful candidate will be responsible for integrating translational research and clinical development, developing a biomarker strategy in alignment with development team objectives, leading efforts for data generation, interpretation and communication. The candidate will also be responsible for understanding the external research environment, partnering with other functions and with external partners, to coordinate the execution of deliverables.

Key Role Accountabilities:

• Independently engages with TM teams and technical/scientific experts to define, revise and progress biomarker plans.
• Delivers high quality biomarker strategies for target engagement, pharmacodynamic endpoints and patient selection.
• Continually analyzes progress, engages in critical thinking, and asserts strong problem-solving toward delivering key data and interpretation essential for decision making on assigned enterprise level efforts
• Ensures the output of the biomarker plans meets established program standards (within budget, on schedule, compliant, etc.), while also looking for opportunities to streamline progress without compromising quality.
• Proactively provides insight into novel ways to incorporate biomarkers into clinical designs to enable early understanding of emerging drug profiles.
• Effectively interfaces with the Translational Medicine group to identify resources needed to deliver on biomarker goals.
• Collaborates and strategizes across the entire Oncology organization to improve efficiency and accelerate the product pipeline forward.
• In partnership with TMTL, communicates key biomarker program information, risks, and milestones, and manages information flow across key stakeholders including therapeutic area leadership, functional leads and team members.
• As appropriate, provides biomarker expertise to progress validated biomarkers into development of pharmacodiagnostic tools

Qualifications:

• MD , PhD, or equivalent advanced biology degree
• Experienced scientist with 9+ years experience in the drug development process.
  • Deep understanding of the role of translational research/medicine and clinical biomarkers in drug development
  • Record of accomplishment in oncology and/or tumor-immunology disease biology
  • Demonstrated experience in the appropriate application various scientific technologies into translational research strategies
  • Working knowledge of all functional areas of drug development, including, biology, toxicology, clinical development, diagnostic development, etc.
• Demonstrated scientific acumen and mechanistic understanding of disease biology
• Ability to multitask across multiple development assets.