RA/Senior Research Associate Molecular Biology and Protein Chemistry
- Employer
- Synthorx, Inc.
- Location
- La Jolla, CA
- Start date
- Jan 18, 2019
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- Discipline
- Science/R&D, Biology, Biotechnology, Cell Biology, Chemistry, Research, Molecular Biology, Oncology
- Required Education
- Bachelors Degree
- Position Type
- Full time
Synthorx is a pharmaceuticals startup company using a novel synthetic biology platform for the discovery and development of transformational protein therapeutics. We are hiring a driven, resourceful Research Associate/Senior Research Associate with strong background in molecular biology and recombinant protein expression, and a working knowledge of protein biochemistry and purification, to join our high-energy team and support projects focused on the identification of lead candidate molecules for immuno-oncology and autoimmune disease indications. We are seeking a self-starting, highly independent and collaborative individual, able to operate at high pace, to meet aggressive timelines.
Key Responsibilities:
- Perform and optimize molecular biology methods for cloning, strain generation and analytical testing
- Hands-on experience with all methods employed for protein expression, purification, and analytical evaluation
- Experimentally determine methods and strategies to optimize yields for protein expression
- Develop standard operating procedures and document protocols
- Prepare and present project updates to ensure timely delivery
- Maintain a high standard for quality control including up-to-date data records for all deliveries
- Troubleshoot challenging technical, experimental, and instrumental issues
- Consummate ability to work in a highly collaborative, fast-paced, cross-functional environment, with superior oral and written communication skills
Required:
- BS or MSc degree, with a major in biochemistry, biology, chemistry, or related field, and 2+ years of hands-on experience with molecular biology and recombinant protein production
- Extensive experience with molecular biology methods including PCR, cloning, and DNA assembly
- Experience developing methods for protein purification.
- Chromatography skills including affinity and SEC. Familiarity with AKTA instrumentation is highly desirable
- Experience in protein characterization (SDS PAGE, Western Blotting, quantification). Understanding of MS methods for QC is a plus
- Regular activities require ability to communicate effectively and rapidly reprioritize to match dynamic and demanding timelines
Additional preferred skills:
- Working knowledge of analytical methods including LC-MS and HPLC
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